The weeks shown in color represent the start and end points of chemical exposure for each study.
|Study Results||Study Details||References|
Results for Dioxin (TCDD)Increased pH3 expression and increased external granular layer thickness on post-natal day 10. Decreased BrdU indicating a reduced number of granule neuroblasts on post-natal day 10. Increased Bax expression on post-natal days 8 and 10 with increased levels and abnormal patterns of apoptsis. Reduced DNA content and GABARAα6 in cerebellar tissue collected post-natal day 21
Subjects: C57BL/6J mice
Chemical: Dioxin (TCDD)
Low doses tested: 1.0 μg/kg bw
Route of administration: dissolved in olive oil and administered by gavage
Exposure duration: post-natal day 6 – single dose (comparable to human prenatal development from approximately day 1 of week 22 to day 1 of week 23)
Age of measurement: post-natal days 7, 8, 10, and 21
|Reference [PubMed Link]
Collins LL, Williamson MA, Thompson BD, Dever DP, Gasiewicz TA, Opanashuk LA. 2008. 2,3,7,8-Tetracholorodibenzo-p-dioxin exposure disrupts granule neuron precursor maturation in the developing mouse cerebellum. Toxicol Sci 103(1):125-136.