The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Phthalates (DBP, DCHP and DEHP)Increased nightime hyperactivity at 4 weeks of age |
Subjects: Wistar rats Chemical: Phthalates (DBP, DCHP and DEHP) Low doses tested: 87 nmol/10 μl/rat(~10 g) Route of administration: injected intracisternally into pups Exposure duration: post-natal day 5 – single dose (comparable to human prenatal development from approximately day 1 of week 25 to day 1 of week 26) Age of measurement: 4 and 8 weeks of age |
Reference [PubMed Link] Ishido M, Morita M, Oka S, Masuo Y. 2005. Alteration of gene expression of G protein-coupled receptors in endocrine disruptors-caused hyperactive rats. Regul Pept 126(1-2):145-153. |
| Study Results | Study Details | References |
Results for Phthalates (DBP, DCHP and DEHP)Decreased gene expression of dopamine transporter in the midbrain |
Subjects: Wistar rats Chemical: Phthalates (DBP, DCHP and DEHP) Low doses tested: 87 nmol/10 μl/rat(~10 g) Route of administration: injected intracisternally into pups Exposure duration: post-natal day 5 – single dose (comparable to human prenatal development from approximately day 1 of week 25 to day 1 of week 26) Age of measurement: 4 and 8 weeks of age |
Reference [PubMed Link] Ishido M, Morita M, Oka S, Masuo Y. 2005. Alteration of gene expression of G protein-coupled receptors in endocrine disruptors-caused hyperactive rats. Regul Pept 126(1-2):145-153. |
| Study Results | Study Details | References |
Results for Phthalates (DCHP)Increased hyperactivity at 4 weeks of age |
Subjects: Wistar rats Chemical: Phthalates (DCHP) Low doses tested: 87 nmol/10 μl/rat(~10 g) Route of administration: injected intracisternally into pups Exposure duration: post-natal day 5 – single dose (comparable to human prenatal development from approximately day 1 of week 25 to day 1 of week 26) Age of measurement: 4 and 8 weeks of age |
Reference [PubMed Link] Ishido M, Masuo Y, Sayato-Suzuki J, Oka S, Niki E, Morita M. 2004 Oct. Dicyclohexylphthalate causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivity. J Neurochem 91(1):69-76. |