The weeks shown in color represent the start and end points of chemical exposure for each study.
|Study Results||Study Details||References|
Results for Bisphenol ADecreased germ cell methylation of Igf2r, Peg3, and H19 at 80 and 160 μg/kg, 40, 80, and 160 μg/kg and 80 and 160 μg/kg, respectively. Decreased vasa and Stra8 mRNA levels and increased mRNA Nobox and ERα levels at the highest dose.
Subjects: CD-1 mice
Chemical: Bisphenol A
Low doses tested: 40.0, 80.0 or 160 μg/kg bw/d
Route of administration: dissolved in DMSO and delievered orally
Exposure duration: gestational day 0.5 – gestational day 12.5 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 6)
Age of measurement: gestational day 12.5
|Reference [PubMed Link]
Zhang XF, Zhang LJ, Feng YN, Chen B, Feng YM, Liang GJ, Li L, Shen W. 2012. Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells. Mol Biol Rep 39(9):8621-8628.