The weeks shown in color represent the start and end points of chemical exposure for each study.
|Study Results||Study Details||References|
Results for Dioxin (TCDD)Decreased testicular testosterone in those treated with 0.3 μg/kg. Decreased 3β-HSD1 at 1.0 μg/kg exposure levels
Subjects: Sprague Dawley rats
Chemical: Dioxin (TCDD)
Low doses tested: 0.3 or 1.0 μg/kg bw
Route of administration: dissolved in corn oil and administered orally
Exposure duration: gestational day 11 – single dose (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 4)
Age of measurement: gestational day 19.5
|Reference [PubMed Link]
Adamsson A, Simanainen U, Viluksela M, Paranko J, Toppari J. 2009. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on foetal male rat steroidogenesis. Int J Androl 32(5):575-585.