The weeks shown in color represent the start and end points of chemical exposure for each study.
|Study Results||Study Details||References|
Results for Dioxin (TCDD)Decreased number and density of nodules.
Subjects: Fetal calvaria cells of rats
Chemical: Dioxin (TCDD)
Low doses tested: 10 nM
Route of administration: in vitro culture
Exposure duration: gestational day 21 – in vitro culture (comparable to human prenatal development from approximately day 1 of week 15 to day 1 of week 18)
Age of measurement: 6, 8, 10 and 21 days in culture
|Reference [PubMed Link]
Gierthy JF, Silkworth JB, Tassinari M, Stein GS, Lian JB. 1994. 2,3,7,8-tetrachlorodibenzo-p-dioxin inhibits differentiation of normal diploid rat osteoblasts in vitro. J Cell Biochem 54(2):231-238.