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The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Increased serum thyroid-stimulating hormone (TSH) with no change in T3 or T4

Subjects: Long-Evans rats

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: post-natal day 1 – single dose (comparable to human prenatal development from approximately day 1 of week 20 to day 1 of week 21)

Age of measurement: 25 days of age

Reference [PubMed Link]
Fenton SE, Hamm JT, Birnbaum LS, Youngblood GL. 2002. Persistent abnormalities in the rat mammary gland following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Sci 67(1):63-74.