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The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Chlorpyrifos

Reduced follicular density per thyroid area unit

Subjects: CD-1 mice

Chemical: Chlorpyrifos

Low doses tested: 3.0 and 0.0, or 3.0 and 1.0, or 3.0 and 3.0 mg/kg/bw/d

Other doses tested: 6 mg/kg bw/d (gestational dose)

Route of administration: Gestational dose was dissolved in peanut oil and given by oral gavage; post-natal dose was injected sub-cutaneously

Exposure duration: gestational day 15 – post-natal day 14 (not continuous) (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 32)

Age of measurement: post-natal day 150

Reference [PubMed Link]
De Angelis S, Tassinari R, Maranghi F, Eusepi A, Di Virgilio A, Chiarotti F, Ricceri L, Venerosi Pesciolini A, Gilardi E, Moracci G, Calamandrei G, Olivieri A, Mantovani A. 2009. Developmental exposure to chlorpyrifos induces alterations in thyroid and thyroid hormone levels without other toxicity signs in CD-1 mice. Toxicol Sci 108(2):311-319.