The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased lymph node cellularity in females esposed to 2.5 μg/kg at 48 weeks of age. Alterations in bone marrow B lymphoid progenitor types in males and females at both exposure groups. Changes in thymic T cell differentiation and splenic B cell and lymph node T cell population distributions in males and females at 5.0 μg/kg. Males exposed to 5.0 μg/kg had increased levels of anti-cardiolipin autoantibodies. At 5.0 μg/kg there were increased INF-γ levels in females and increased IL-10 levels in males. |
Subjects: C57BL/6J mice Chemical: Dioxin (TCDD) Low doses tested: 2.5 or 5.0 μg/kg bw Route of administration: dissolved in corn oil and administered by gavage Exposure duration: gestational day 12 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6) Age of measurement: 48 weeks of age |
Reference [PubMed Link] Mustafa A, Holladay SD, Witonsky S, Sponenberg DP, Karpuzoglu E, Gogal RM Jr. 2011. A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice. Toxicology 290(2-3):156-168. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased thymus weight and cellularity in females exposed to 5.0 μg/kg at 48 weeks of age |
Subjects: C57BL/6J mice Chemical: Dioxin (TCDD) Low doses tested: 2.5 or 5.0 μg/kg bw Route of administration: dissolved in corn oil and administered by gavage Exposure duration: gestational day 12 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6) Age of measurement: 48 weeks of age |
Reference [PubMed Link] Mustafa A, Holladay SD, Witonsky S, Sponenberg DP, Karpuzoglu E, Gogal RM Jr. 2011. A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice. Toxicology 290(2-3):156-168. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased relative spleen weight on post-natal day 14. Alterations in the expression of CD44 and CD45/CD90 on post-natal days 1 and 46 respectively. |
Subjects: C57BL/6 mice Chemical: Dioxin (TCDD) Low doses tested: 5.0 μg/kg bw Route of administration: dissolved in corn oil and administered by gavage Exposure duration: gestational day 12 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6) Age of measurement: post-natal days 1, 14, 25, and 46 |
Reference [PubMed Link] Weinstein DA, Gogal RM Jr, Mustafa A, Prater MR, Holladay SD. 2008. Mid-gestation exposure of C57BL/6 mice to 2,3,7,8-tetrachlorodibenzo-p-dioxin causes postnatal morphologic changes in the spleen and liver. Toxicol Pathol 36(5):705-713. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased relative thymus weight on post-natal day 1. Increased thymic apoptic index on post-natal day 1. |
Subjects: C57BL/6 mice Chemical: Dioxin (TCDD) Low doses tested: 5.0 μg/kg bw Route of administration: dissolved in corn oil and administered by gavage Exposure duration: gestational day 12 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6) Age of measurement: post-natal days 1, 14, 25, and 46 |
Reference [PubMed Link] Weinstein DA, Gogal RM Jr, Mustafa A, Prater MR, Holladay SD. 2008. Mid-gestation exposure of C57BL/6 mice to 2,3,7,8-tetrachlorodibenzo-p-dioxin causes postnatal morphologic changes in the spleen and liver. Toxicol Pathol 36(5):705-713. |