References popup

The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for PFAS (PFOS)

Alterations in the expression in genes involved in secreted, cytoskeletal structure, extracellular matrix, ion channel and transporting, lipid metabolic, and transcription/ translation proteins.

Subjects: Sprague-Dawley rats

Chemical: PFAS (PFOS)

Low doses tested: 5.0 mg/kg bw/d

Other doses tested: 20.0 mg/kg bw/d

Route of administration: dissolved in Tween-20 and delivered through gavage

Exposure duration: gestational day 12 – gestational day 18 (comparable to human prenatal development from approximately day 1 of week 4 to day 1 of week 9)

Age of measurement: gestational day 18.5

Reference [PubMed Link]
Ye L, Zhao B, Yuan K, Chu Y, Li C, Zhao C, Lian QQ, Ge RS. 2012. Gene expression profiling in fetal rat lung during gestational perfluorooctane sulfonate exposure. Toxicol Lett 209(3):270-276.