Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

4-methylcatechol

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CAS # 452-86-8

Categories*
Medical/Veterinary/Research
Metabolite/Degradate

Evidence Supporting This Chemical as an Endocrine Disruptor

Lindsay RH, Hill JB, Gaitan E, Cooksey RC, Jolley RL. 1992. Antithyroid effects of coal-derived pollutants. J Toxicol Environ Health 37(4):467-481.

*Category References

Fukuhara K, Ishikawa K, Yasuda S, Kishishita Y, Kim HK, Kakeda T, Yamamoto M, Norii T, Ishikawa T. 2012. Intracerebroventricular 4-methylcatechol (4-MC) ameliorates chronic pain associated with depression-like behavior via induction of brain-derived neurotrophic factor (BDNF). Cell Mol Neurobiol 32(6):971-977

Ju KS, Parales RE. 2011. Evolution of a new bacterial pathway for 4-nitrotoluene degradation. Mol Microbiol 82(2):355-364

Lu J, Gao X, Gu J, Zhou L, Guo S, Hao W, Zhou Z, Cao JM. 2012. Nerve sprouting contributes to increased severity of ventricular tachyarrhythmias by upregulating iGluRs in rats with healed myocardial necrotic injury. J Mol Neurosci 48(2):448-455

Payton F, Bose R, Alworth WL, Kumar AP, Ghosh R. 2011. 4-Methylcatechol-induced oxidative stress induces intrinsic apoptotic pathway in metastatic melanoma cells. Biochem Pharmacol 81(10):1211-1218

US National Library of Medicine. Haz-Map. [http://hazmap.nlm.nih.gov/index.php].

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