Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

4-nonylphenol

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CAS # 104-40-5

Alternative Name

p-nonylphenol

Categories*
Byproduct/Intermediate/Reactant
Industrial additive
Medical/Veterinary/Research
Metabolite/Degradate
Pesticide ingredient
Plastic/Rubber

Evidence Supporting This Chemical as an Endocrine Disruptor

Bonefeld-Jorgensen EC, Long M, Hofmeister MV, Vinggaard AM. 2007. Endocrine-disrupting potential of bisphenol A, bisphenol A dimethacrylate, 4-n-nonylphenol, and 4-n-octylphenol in vitro: new data and a brief review. Environ Health Perspect 115 Suppl 1:69-76.

Jobling S, Sheahan D, Osborne JA, Matthiessen P, Sumpter JP. 1996. Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals. Environ Toxicol Chem 15(2):194-202.

Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J. 2005. Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor [gamma]/retinoid X receptor pathway. Mol Pharmacol 67(3):766-774.

Matsunaga H, Mizota K, Uchida H, Uchida T, Ueda H. 2010. Endocrine disrupting chemicals bind to a novel receptor, microtubule-associated protein 2, and positively and negatively regulate dendritic outgrowth in hippocampal neurons. J Neurochem 114(5):1333-1343.

Soto AM, Justicia H, Wray JW, Sonnenschein C. 1991. p-Nonyl-phenol: An estrogenic xenobiotic released from "modified" polystyrene. Environ Health Perspect 92:167-173.

Tran DQ, Klotz DM, Ladlie BL, Ide CF, McLachlan JA, Arnold SF. 1996. Inhibition of progesterone receptor activity in yeast by synthetic chemicals. Biochem Biophys Res Commun 229(2):518-523.

*Category References

Rey Vazquez G, Meijide FJ, Da Cuna RH, Lo Nostro FL, Piazza YG, Babay PA, Trudeau VL, Maggese MC, Guerrero GA. 2009. Exposure to waterborne 4-tert-octylphenol induces vitellogenin synthesis and disrupts testis morphology in the South American freshwater fish Cichlasoma dimerus (Teleostei, Perciformes). Comp Biochem Physiol C Toxicol Pharmacol 150(2):298-306, doi: 10.1016/j.cbpc.2009.05.012

US National Library of Medicine. Haz-Map. [http://hazmap.nlm.nih.gov/index.php].

US National Library of Medicine. Hazardous Substances Data Bank. [http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB].

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