Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
butyl benzyl phthalate
CAS # 85-68-7
Alternative Name
benzyl butyl phthalate (BBP)
Categories*
Byproduct/Intermediate/Reactant
Household product ingredient
Industrial additive
Plastic/Rubber
Unconventional Oil and Gas
Evidence Supporting This Chemical as an Endocrine Disruptor
Coldham NG, Dave M, Sivapathasundaram S, Mcdonnell DP, Connor C, Sauer MJ. 1997. Evaluation of a recombinant yeast cell estrogen screening assay. Environ Health Perspect 105(7):734-742.
Jobling S, Reynolds T, White R, Parker MG, Sumpter JP. 1995. A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ Health Perspect 103(6):582-587.
Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J. 2005. Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor [gamma]/retinoid X receptor pathway. Mol Pharmacol 67(3):766-774.
Lampen A, Zimnik S, Nau H. 2003. Teratogenic phthalate esters and metabolites activate the nuclear receptors PPARs and induce differentiation of F9 cells. Toxicol Appl Pharmacol 188(1):14-23.
Lu KY, Tseng FW, Wu CJ, Liu PS. 2004. Suppression by phthalates of the calcium signaling of human nicotinic acetylcholine receptors in human neuroblastoma SH-SY5Y cells. Toxicology 200(2-3):113-121.
*Category References
Orem WH, Tatu CA, Lerch HE, Rice CA, Bartos TT, Bates AL, Tewalt S, Corum MD. 2007. Organic compounds in produced waters from coalbed natural gas wells in the Powder River Basin, Wyoming, USA. Appl Geochem 22(10):2240-2256.
US Dept of Health & Human Services. Household Products Database.
US National Library of Medicine. Haz-Map.
US National Library of Medicine. Hazardous Substances Data Bank.