Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
butylated hydroxyanisole
CAS # 25013-16-5
Alternative Names
BHA
t-butylhydroxyanisole
2(3)-tert-butyl-4-hydroxyanisole
Categories*
Food additives and contact material
Industrial additive
Personal care product/Cosmetic ingredient
Pesticide ingredient
Plastic/Rubber
Evidence Supporting This Chemical as an Endocrine Disruptor
Jeong SH, Kim BY, Kang HG, Ku HO, Cho JH. 2005. Effects of butylated hydroxyanisole on the development and functions of reproductive system in rats. Toxicology 208(1):49-62.
Kang HG, Jeong SH, Cho JH, Kim DG, Park JM, Cho MH. 2005. Evaluation of estrogenic and androgenic activity of butylated hydroxyanisole in immature female and castrated rats. Toxicology 213(1-2):147-156.
Okubo T, Kano I. 2003. [Studies on estrogenic activities of food additives with human breast cancer MCF-7 cells and mechanism of estrogenicity by BHA and OPP]. Yakugaku Zasshi 123(6):443-452.
Soto AM, Sonnenschein C, Chung KL, Fernandez MF, Olea N, Serrano FO. 1995. The E-SCREEN assay as a tool to identify estrogens: An update on estrogenic environmental pollutants. Environ Health Perspect 103 (Suppl 7):113-122.
ter Veld MGR, Schouten B, Louisse J, Van Es DS, Van Der Saag PT, Rietjens IMCM, Murk AJ. 2006. Estrogenic potency of food-packaging-associated plasticizers and antioxidants as detected in ERalpha and ERbeta reporter gene cell lines. Journal of Agricultural & Food Chemistry 54(12):4407-4416.
*Category References
US Dept of Health & Human Services. Household Products Database.
US EPA. InertFinder.
US National Library of Medicine. Haz-Map.
US National Library of Medicine. Hazardous Substances Data Bank.