Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

2,2',4,4'-tetrabromodiphenyl ether


CAS # 5436-43-1

Alternative Name


Flame retardant
Industrial additive

Evidence Supporting This Chemical as an Endocrine Disruptor

Hamers T, Kamstra JH, Sonneveld E, Murk AJ, Kester MH, Andersson PL, Legler J, Brouwer A. 2006. In vitro profiling of the endocrine-disrupting potency of brominated flame retardants. Toxicol Sci 92(1):157-173; DOI: 10.1093/toxsci/kfj187.

Hamers T, Kamstra JH, Sonneveld E, Murk AJ, Visser TJ, Van Velzen MJM, Brouwer A, Bergman Å. 2008. Biotransformation of brominated flame retardants into potentially endocrine-disrupting metabolites, with special attention to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47). Mol Nutr Food Res 52(2):284-298; DOI: 10.1002/mnfr.200700104.

Meerts IATM, Letcher RJ, Hoving S, Marsh G, Bergman Å, Lemmen JG, van der Burg B, Brouwer A. 2001. In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PBDEs, and polybrominated bisphenol A compounds. Environ Health Perspect 109(4):399-407; DOI: 10.2307/3454900.

*Category References

WHO. 1994. Brominated diphenyl ethers. Environmental Health Criteria 162 [www.inchem.org/documents/ehc/ehc/ehc162.htm].