Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

methyl tertiary butyl ether

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CAS # 1634-04-4

Alternative Names

methyl tert-butyl ether

MTBE

Categories*
Byproduct/Intermediate/Reactant
Household product ingredient
Industrial additive
Medical/Veterinary/Research
Solvent

Evidence Supporting This Chemical as an Endocrine Disruptor

de Peyster A, Stanard B, Westover C. 2009. Effect of ETBE on reproductive steroids in male rats and rat Leydig cell cultures. Toxicol Lett 190(1):74-80.

Li DM, Han XD. 2006. Evaluation of toxicity of methyl tert-butyl ether (MTBE) on mouse spermatogenic cells in vitro. Toxicol Ind Health 22(7):291-299.

Williams TM, Borghoff SJ. 2000. Induction of testosterone biotransformation enzymes following oral administration of methyl tert-butyl ether to male Sprague-Dawley rats. Toxicol Sci 57(1):147-155.

Williams TM, Cattley RC, Borghoff SJ. 2000. Alterations in endocrine responses in male Sprague-Dawley rats following oral administration of methyl tert-butyl ether. Toxicol Sci 54(1):168-176.

Zheng G, Zhang W, Zhang Y, Chen Y, Liu M, Yao T, Yang Y, Zhao F, Li J, Huang C, Luo W, Chen J. 2009. [gamma]-Aminobutyric acid(A) (GABA(A)) receptor regulates ERK1/2 phosphorylation in rat hippocampus in high doses of methyl tert-butyl ether (MTBE)-induced impairment of spatial memory. Toxicol Appl Pharmacol 236(2):239-245, doi: 10.1016/j.taap.2009.01.004.

*Category References

US National Library of Medicine. Haz-Map. [http://hazmap.nlm.nih.gov/index.php].

US National Library of Medicine. Hazardous Substances Data Bank. [http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB].

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