Endocrine Disruption

TEDX List of Potential Endocrine Disruptors



CAS # 1836-75-5

Alternative Names


2,4-dichlorophenyl-p-nitrophenyl ether

niclofen (Canada)

NIP (Japan)

Pesticide ingredient

Evidence Supporting This Chemical as an Endocrine Disruptor

Gray LE Jr., Kavlock RJ, Chernoff N, Ostby J, Ferrel J. 1983. Postnatal developmental alterations following prenatal exposure to the herbicide 2,4-dichlorophenyl-p-nitrophenyl ether: A dose response evaluation in the mouse. Toxicol Appl Pharmacol 67(1):1-14.

Gray LE Jr., Kavlock RJ. 1983. The effects of the herbicide 2,4-dichlorophenyl-p-nitrophenyl ether (NIT) on serum thyroid hormones in adult female mice. Toxicol Lett 15(2-3):231-235.

Kojima H, Katsura E, Takeuchi S, Niiyama K, Kobayashi K. 2004. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect 112(5):524-531.

Okubo T, Yokoyama Y, Kano K, Soya Y, Kano I. 2004. Estimation of estrogenic and antiestrogenic activities of selected pesticides by MCF-7 cell proliferation assay. Arch Environ Contam Toxicol 46(4):445-453.

Yamada-Okabe T, Sakai H, Kashima Y, Yamada-Okabe H. 2005. Modulation at a cellular level of the thyroid hormone receptor-mediated gene expression by 1,2,5,6,9,10-hexabromocyclododecane (HBCD), 4,4'-diiodobiphenyl (DIB), and nitrofen (NIP). Toxicol Lett 155(1):127-133.

*Category References

Compendium of Pesticide Common Names (CPCN).

INCHEM. 1996. Nitrofen. WHO/FAO Data Sheets on Pesticides No. 84.

PAN-Europe. 2006. What substances are banned and authorised in the EU market? .

US National Library of Medicine. Hazardous Substances Data Bank.