Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

p-cresol

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CAS # 106-44-5 / 1319-77-3

Alternative Name

4-methylphenol

Categories*
Antimicrobial
Food additive
Household product ingredient
Household product ingredient
Household product ingredient
Household product ingredient
Industrial additive
Pesticide ingredient

Evidence Supporting This Chemical as an Endocrine Disruptor

Dietz, D. NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).. Toxicity report series, 1991, 9: 1-128. PMID:12209177.

Kawakami K, Makino I, Kato I, Uchida K, Onoue M. 2009. p-Cresol inhibits IL-12 production by murine macrophages stimulated with bacterial immunostimulant. Immunopharmacol Immunotoxicol 31(2):304-309.

Nakamura M, Yamazaki I, Kotani T, Ohtaki S. 1989. Thyroglobulin-mediated one- and two-electron oxidations of glutathione and ascorbate in thyroid peroxidase systems. J Biol Chem 264(22):12909-12913.

Nishihara T, Nishikawa J, Kanayama T, Dakeyama F, Saito K, Imagawa M, Takatori S, Kitagawa Y, Hori S, Utsumi H. 2000. Estrogenic activities of 517 chemicals by yeast two-hybrid assay. Journal of Health Science 46(4):282-298.

Thompson DC, Perera K, Fisher R, Brendel K. 1994. Cresol isomers: comparison of toxic potency in rat liver slices. Toxicol Appl Pharmacol 125(1):51-58.

*Category References

US EPA. InertFinder. [http://iaspub.epa.gov/apex/pesticides/f?p=175:1:].

US National Library of Medicine. Hazardous Substances Data Bank. [http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB].

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