Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
perfluorohexanoic acid
CAS # 307-24-4
Alternative Names
PFHxA
perfluoro-n-hexanoic acid
undecafluorohexanoic acid
Categories*
Flame retardant
Household product ingredient
Industrial additive
Personal care product/Cosmetic ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Li Y, Cheng Y, Xie Z and Zeng F. 2017. Perfluorinated alkyl substances in serum of the southern Chinese general population and potential impact on thyroid hormones. Scientific Reports 7:43380.
Vongphachan V, Cassone CG, Wu D, Chiu S, Crump D, Kennedy SW. 2011. Effects of perfluoroalkyl compounds on mRNA expression levels of thyroid hormone-responsive genes in primary cultures of avian neuronal cells. Toxicol Sci 120(2):392-402.
Wolf CJ, Takacs ML, Schmid JE, Lau C, Abbott BD. 2008. Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths. Toxicol Sci 106(1):162-171.
*Category References
Houtz EF, Higgins CP, Field JA and Sedlak DL. 2013. Persistence of perfluoroalkyl acid precursors in AFFF-impacted groundwater and soil. Environ Sci Technol 47(15):8187-8195.
Jensen AA, Leffers H. 2008. Emerging endocrine disrupters: perfluoroalkylated substances. Int J Androl 31(2):161-169.
Rosenmai AK, Taxvig C, Svingen T, Trier X, Vugt‐Lussenburg BMA, Pedersen M, Lesné L, Jégou B and Vinggaard AM. 2016. Fluorinated alkyl substances and technical mixtures used in food paper‐packaging exhibit endocrine‐related activity in vitro. Andrology 4(4):662-672.
Zafeiraki E, Costopoulou D, Vassiliadou I, Bakeas E and Leondiadis L. 2014. Determination of perfluorinated compounds (PFCs) in various foodstuff packaging materials used in the Greek market. Chemosphere, 94:169-176.