Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

triclosan

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CAS # 3380-34-5

Alternative Names

TCS

2'-hydroxy-2,4,4'-trichlorodiphenyl ether

2'-OH-PCDE-28

2,4,4'-trichloro-2'-hydroxydiphenyl ether

Irgasan

Categories*
Antimicrobial
Household product ingredient
Industrial additive
Medical/Veterinary/Research
Personal care product/Cosmetic ingredient
Pesticide ingredient
Plastic/Rubber

Evidence Supporting This Chemical as an Endocrine Disruptor

Ahn KC, Zhao B, Chen J, Cherednichenko G, Sanmarti E, Denison MS, Lasley B, Pessah IN, Kultz D, Chang DPY, Gee SJ, Hammock BD. 2008. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: Receptor-based bioassay screens. Environ Health Perspect 116(9):1203-1210.

Zorrilla LM, Gibson EK, Jeffay SC, Crofton KM, Setzer WR, Cooper RL, Stoker TE. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicol Sci 107(1):56-64.

*Category References

US Dept of Health & Human Services. Household Products Database. [http://hpd.nlm.nih.gov/].

US EPA. 2008. Reregistration Eligibility Decision for Triclosan. http://www.epa.gov/oppsrrd1/REDs/2340red.pdf

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