Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

isobutyl paraben


CAS # 4247-02-3

Alternative Name

isobutyl p-hydroxybenzoate

Personal care product/Cosmetic ingredient

Evidence Supporting This Chemical as an Endocrine Disruptor

Darbre PD, Byford JR, Shaw LE, Horton RA, Pope GS, Sauer MJ. 2002. Oestrogenic activity of isobutylparaben in vitro and in vivo. J Appl Toxicol 22(4):219-226; DOI:10.1002/jat.860.

Okubo T, Yokoyama Y, Kano K, Kano I. 2001. ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ER[alpha] and PR. Food Chem Toxicol 39(12):1225-1232; DOI: 10.1016/S0278-6915(01)00073-4.

Terasaki M, Kamata R, Shiraishi F, Makino M. 2009. Evaluation of estrogenic activity of parabens and their chlorinated derivatives by using the yeast two-hybrid assay and the enzyme-linked immunosorbent assay. Environ Toxicol Chem 28(1):204-208; DOI: 10.1897/08-225.1.

Vo TT, Jeung EB. 2009. An evaluation of estrogenic activity of parabens using uterine calbindin-d9k gene in an immature rat model. Toxicol Sci 112(1):68-77; DOI:10.1093/toxsci/kfp176.

*Category References

Drugs.com [www.drugs.com/inactive/isobutylparaben-521.html‎]

EWG [www.ewg.org/skindeep/ingredient/703160/ISOBUTYLPARABEN/]