Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

isopropyl paraben


CAS # 4191-73-5

Alternative Name

isopropyl p-hydroxybenzoate

Personal care product/Cosmetic ingredient

Evidence Supporting This Chemical as an Endocrine Disruptor

Okubo T, Yokoyama Y, Kano K, Kano I. 2001. ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ER[alpha] and PR. Food Chem Toxicol 39(12):1225-1232; DOI: 10.1016/S0278-6915(01)00073-4.

Terasaki M, Kamata R, Shiraishi F, Makino M. 2009. Evaluation of estrogenic activity of parabens and their chlorinated derivatives by using the yeast two-hybrid assay and the enzyme-linked immunosorbent assay. Environ Toxicol Chem 28(1):204-208; DOI: 10.1897/08-225.1.

Vo TT, Jeung EB. 2009. An evaluation of estrogenic activity of parabens using uterine calbindin-d9k gene in an immature rat model. Toxicol Sci 112(1):68-77; DOI:10.1093/toxsci/kfp176.

*Category References

EWG [www.ewg.org/skindeep/ingredient/703212/ISOPROPYLPARABEN/]