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Critical Windows of Development Timeline

References

References cited in the Critical Windows of Development timeline:

Normal Human Development

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Bayer SA, Altman J, Russo RJ, Zhang X. 1993. Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology 14(1):83-144.

Bernal J, Pekonen F. 1984. Ontogenesis of the nuclear 3,5,3’-triiodothyronine receptor in the human fetal brain. Endocrinology 114(2):677-679.

Boukari K, Ciampi ML, Guiochon-Mantel A, Young J, Lombes M, Meduri G. 2007 Jul. Human fetal testis: source of estrogen and target of estrogen action. Hum Reprod 22(7):1885-92.

Chan S, Rovet J. 2003. Thyroid hormones in fetal central nervous system development. Fetal & Maternal Medicine Review 14(3):177-208.

Contempre B, Jauniaux E, Calvo R, Jurkovic D, Campbell S, Morreale de Escobar G. 1993. Detection of thyroid hormones in human embryonic cavities during the first trimester of pregnancy. Journal of Clinical Endocrinology & Metabolism 77(6):1719-1722.

Cunha GR, Donjacour AA, Cooke PS, Mee S, Bigsby RM, Higgins SJ, Sugimura Y. 1987. The endocrinology and developmental biology of the prostate. Endocr Rev 8:338-362.

Delbes G, Levacher C, Habert R. 2006. Estrogen effects on fetal and neonatal testicular development. Reproduction 132(4):527-538.

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Fisher DA. 1997. Fetal thyroid function: Diagnosis and management of fetal thyroid disorders. Clinical Obstetrics & Gynecology 40(1):16-31.

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Glatstein IZ, Yeh J. 1995. Ontogeny of the estrogen receptor in the human fetal uterus. Journal of Clinical Endocrinology & Metabolism 80(3):958-964.

Gould DA, Moscoso GJ, Young MP, Barton DP. 2000. Human first trimester fetal ovaries express oncofetal antigens and steroid receptors. J Soc Gynecol Investig 7(2):131-138.

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Gusterson BA, Stein T. 2012. Human breast development. Seminars in Cell and Developmental Biology 23(5):567-573.

Hahn von Dorsche H, Falkmer S. 2000. Ontogenesis of human islets of Langerhans. Review of light and electron microscopic data, immunohistochemical and functional data on fetal development of the endocrine pancreas. Journal of Evolutionary Biochemistry and Physiology 36(6):701-718.

Hannema SE, Hughes IA. 2007. Regulation of Wolffian duct development. Horm Res 67(3):142-151.

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Kaplan SL, Grumbach MM, Aubert ML. 1976. The ontogenesis of pituitary hormones and hypothalamic factors in the human fetus: maturation of central nervous system regulation of anterior pituitary function. Recent Prog Horm Res 32:161-243.

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Marker PC, Donjacour AA, Dahiya R, Cunha GR. 2003. Hormonal, cellular, and molecular control of prostatic development. Dev Biol 253(2):165-174.

Migliaccio G, Migliaccio AR, Petti S, Mavilio F, Russo G, Lazzaro D, Testa U, Marinucci M, Peschle C. 1986. Human embryonic hemopoiesis. Kinetics of progenitors and precursors underlying the yolk sac----liver transition. The Journal of Clinical Investigation 78(1):51-60

Montgomery RK, Mulberg AE, Grand RJ. 1999. Development of the human gastrointestinal tract: twenty years of progress. Gastroenterology 116(3):702-731.

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O’Rahilly R, Muller F. 1999. The embryonic human brain. An atlas of developmental stages. Second edition. New York: Wiley-Liss.

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Pepe GJ, Albrect ED. 1990. Regulation of the primate fetal adrenal cortex. Endcrine Reviews 11(1):151-176.

Picton HM. 2001. Activation of follicle development: the primordial follicle. Theriogenology 55(6):1193-1210.

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Prince FP. 2001. The triphasic nature of Leydig cell development in humans, and comments on nomenclature. J Endocrinol 168(2):213-6.

Pryor JL, Hughes C, Foster W, Hales BF, Robaire B. 2000. Critical windows of exposure for children’s health: the reproductive system in animals and humans. Environ Health Perspect 108 (Suppl 3):491-503.

Rabinovici J, Jaffe RB. 1990. Development and regulation of growth and differentiated function in human and subhumand primate fetal gonads. Endocrine Reviews 11(4):532-557.

Rajpert-De Meyts E, Jorgensen N, Graem N, Muller J, Cate RL, Skakkebaek NE. 1999. Expression of anti-Mullerian hormone during normal and pathological gonadal development: association with differentiation of Sertoli and granulosa cells. Journal of Clinical Endocrinology & Metabolism 84(10):3836-3844.

Russo J, Russo IH. 2004. Development of the human breast. Maturitas 49(1):2-15.

Sadler TW. 2000. Susceptible periods during embryogenesis of the heart and endocrine glands. Environ Health Perspect 108 (suppl 3):555-561.

Sadler TW. 2004. Langman’s Medical Embryology. Ninth Edition. Maryland: Lippincott Williams & Wilkins.

Satoh M. 1991. Histogenisis and organogenisis of the gonad in human embryos. J. Anat 177:85-107.

Sharpe RM, McKinnell C, Kivlin C, Fisher JS. 2003. Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood. Reproduction 125(6):769-784.

Shepard TH. 1967. Onset of function in the human fetal thyroid: Biochemical and radioautographic studies from organ culture. Journal of Clinical Endocrinology & Metabolism 27(7):945-958.

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Sizonenko PC. 1993. Sexual differentiation. In: Bertrand J, Rappaport R, Sizonenko PC, eds. Pediatric Endocrinology. Baltimore, MD: Williams & Wilkins.

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Thliveris JA, Currie RW. 1980. Observations on the hypothalamo-hypophyseal portal vasculature in the developing human fetus. Am J Anat 157(4):441-444.

Vaskivuo TE, Maentausta M, Torn S, Oduwole O, Lonnberg A, Herva R, Isomaa V, Tapanainen JS. 2005. Estrogen receptors and estrogen-metabolizing enzymes in human ovaries during fetal development. Journal of Clinical Endocrinology & Metabolism 90(6):3752-3756.

vom Saal FS, Montano MM, Wang MH. 1992. Sexual differentiation in mammals. In: Colborn T, Clement C, eds. Chemically Induced Alterations in Sexual and Functional Development: The Wildlife/Human ConnectionVolume XXI. Princeton, NJ: Princeton Scientific Publishing Co., Inc. p 17-83. (Mehlman MA, ed. Advances in Modern Environmental Toxicology; 21).

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Winters AJ, Eskay RL, Porter JC. 1974. Concentration and distribution of TRH and LRH in the human fetal brain. Journal of Clinical Endocrinology & Metabolism 39(5):960-963.

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Bisphenol A

Adriani W, Della Seta D, Dessi-Fulgheri F, Farabollini F, Laviola G. 2003. Altered profiles of spontaneous novelty seeking, impulsive behavior, and response to D-amphetamine in rats perinatally exposed to bisphenol A. Environ Health Perspect 111(4):395-401.

Aikawa H, Koyama S, Matsuda M, Nakahashi K, Akazome Y, Mori T. 2004. Relief effect of vitamin A on the decreased motility of sperm and the increased incidence of malformed sperm in mice exposed neonatally to bisphenol A. Cell & Tissue Research 315(1):119-124.

Akingbemi BT, Sottas CM, Koulova AI, Klinefelter GR, Hardy MP. 2004. Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells. Endocrinology 145(2):592-603.

Aloisi AM, Della Seta D, Rendo C, Ceccarelli I, Scaramuzzino A, Farabollini F. 2002. Exposure to the estrogenic pollutant bisphenol A affects pain behavior induced by subcutaneous formalin injection in male and female rats. Brain Res 937(1-2):1-7.

Ayyanan A, Laribi O, Schuepbach-Mallepell S, Schrick C, Gutierrez M, Tanos T, Lefebvre G, Rougemont J, Yalcin-Ozuysal O, Brisken C. 2011. Perinatal exposure to bisphenol A increases adult mammary gland progesterone response and cell number. Mol Endocrinol 25(11):1915-1923.

Bai Y, Chang F, Zhou R, Jin PP, Matsumoto H, Sokabe M, Chen L. 2011. Increase of anteroventral periventricular kisspeptin neurons and generation of E2-induced LH-surge system in male rats exposed perinatally to environmental dose of bisphenol-A. Endocrinology 152(4):1562-1571.

Bauer SM, Roy A, Emo J, Chapman TJ, Georas SN, Lawrence BP. 2012. The effects of maternal exposure to bisphenol A on allergic lung inflammation into adulthood. Toxicol Sci 130(1):82-93.

Betancourt AM, Mobley JA, Russo J, Lamartiniere CA. 2010. Proteomic analysis in mammary glands of rat offspring exposed in utero to bisphenol A. J Proteomics 73(6):1241-1253.

Brannick KE, Craig ZR, Himes AD, Peretz JR, Wang W, Flaws JA, Raetzman LT. 2012. Prenatal exposure to low doses of bisphenol a increases pituitary proliferation and gonadotroph number in female mice offspring at birth. Biol Reprod 87(4):82.

Chao HH, Zhang XF, Chen B, Pan B, Zhang LJ, Li L, Sun XF, Shi QH, Shen W. 2012. Bisphenol A exposure modifies methylation of imprinted genes in mouse oocytes via the estrogen receptor signaling pathway. Histochem Cell Biol 137(2):249-259.

Dessi-Fulgheri F, Porrini S, Farabollini F. 2002. Effects of perinatal exposure to bisphenol A on play behavior of female and male juvenile rats. Environ Health Perspect 110 (suppl 3):403-407.

Doshi T, Mehta SS, Dighe V, Balasinor N, Vanage G. 2011. Hypermethylation of estrogen receptor promoter region in adult testis of rats exposed neonatally to bisphenol A. Toxicology 289(2-3):74-82.

Durando M, Kass L, Piva J, Sonnenschein C, Soto AM, Luque E, Munoz-de-Toro M. 2007. Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar rats. Environ Health Perspect 115(1):80-86.

Facciolo RM, Alo R, Madeo M, Canonaco M, Dessi-Fulgheri F. 2002. Early cerebral activities of the environmental estrogen bisphenol A appear to act via the somatostatin receptor subtype sst2. Environ Health Perspect 110 (suppl 3):397-402.

Farabollini F, Porrini S, Della Seta D, Bianchi F, Dessi-Fulgheri F. 2002. Effects of perinatal exposure to bisphenol A on sociosexual behavior of female and male rats. Environ Health Perspect 110 (suppl 3):409-413.

Farabollini F, Porrini S, Dessi-Fulgherit F. 1999. Perinatal exposure to the estrogenic pollutant bisphenol A affects behavior in male and female rats. Pharmacology, Biochemistry & Behavior 64(4):687-694.

Ferguson SA, Law CD, Abshire JS. 2012. Developmental treatment with bisphenol A causes few alterations on measures of postweaning activity and learning. Neurotoxicol Teratol 34(6):598-606.

Gioiosa L, Fissore E, Ghirardelli G, Parmigiani S, Palanza P. 2007. Developmental exposure to low-dose estrogenic endocrine disruptors alters sex differences in exploration and emotional responses in mice. Hormones & Behavior 52(3):307-16.

Goncalves CR, Cunha RW, Barros DM, Martinez PE. 2010. Effects of prenatal and postnatal exposure to a low dose of bisphenol A on behavior and memory in rats. Environ Toxicol Pharmacol 30(2):195-201.

Gupta C. 2000. Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals. Proceedings of the Society of Experimental Biology & Medicine 224(2):61-68.

Ho SM, Tang WY, De Frausto JB, Prins GS. 2006. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res 66(11):5624-5632.

Honma S, Suzuki A, Buchanan DL, Katsu Y, Watanabe H, Iguchi T. 2002. Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction. Reprod Toxicol 16(2):117-122.

Howdeshell KL, vom Saal FS. 2000. Developmental exposure to bisphenol A: Interaction with endogenous estradiol during pregnancy in mice. Am Zool 40(3):429-437.

Ishido M, Morita M, Oka S, Masuo Y. 2005. Alteration of gene expression of G protein-coupled receptors in endocrine disruptors-caused hyperactive rats. Regul Pept 126(1-2):145-153.

Jang YJ, Park HR, Kim TH, Yang WJ, Lee JJ, Choi SY, Oh SB, Lee E, Park JH, Kim HP, Kim HS, Lee J. 2012. High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations. Toxicology 296(1-3):73-82.

Jones BA, Watson NV. 2012. Perinatal BPA exposure demasculinizes males in measures of affect but has no effect on water maze learning in adulthood. Horm Behav 61(4):605-610.

Kang ER, Iqbal K, Tran DA, Rivas GE, Singh P, Pfeifer GP, Szabo PE. 2011. Effects of endocrine disruptors on imprinted gene expression in the mouse embryo. Epigenetics 6(7):937-950.

Kass L, Altamirano GA, Bosquiazzo VL, Luque EH, Munoz-de-Toro M. 2012. Perinatal exposure to xenoestrogens impairs mammary gland differentiation and modifies milk composition in Wistar rats. Reprod Toxicol 33(3):390-400.

Kawai K, Murakami S, Senba E, Yamanaka T, Fujiwara Y, Arimura C, Nozaki T, Takii M, Kubo C. 2007. Changes in estrogen receptors alpha and beta expression in the brain of mice exposed prenatally to bisphenol A. Regulatory Toxicology & Pharmacology 47(2):166-170.

Kawai K, Nozaki T, Nishikata H, Takii M, Kubo C. 2003. Aggressive behavior and serum testosterone concentration during the maturation process of male mice: The effects of fetal exposure to bisphenol A. Environ Health Perspect 111(2):175-178.

Kobayashi K, Ohtani K, Kubota H, Miyagawa M. 2010. Dietary exposure to low doses of bisphenol A: effects on reproduction and development in two generations of C57BL/6J mice. Congenit Anom (Kyoto) 50(3):159-170.

Komada M, Asai Y, Morii M, Matsuki M, Sato M, Nagao T. 2012. Maternal bisphenol A oral dosing relates to the acceleration of neurogenesis in the developing neocortex of mouse fetuses. Toxicology 295(1-3):31-38.

Kubo K, Arai O, Omura M, Watanabe R, Ogata R, Aou S. 2003. Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats. Neurosci Res 45(3):345-356.

Losa-Ward SM, Todd KL, McCaffrey KA, Tsutsui K, Patisaul HB. 2012. Disrupted organization of RFamide pathways in the hypothalamus is associated with advanced puberty in female rats neonatally exposed to bisphenol A. Biol Reprod 87(2):28.

Markey CM, Coombs MA, Sonnenschein C, Soto AM. 2003. Mammalian development in a changing environment: exposure to endocrine disruptors reveals the developmental plasticity of steroid-hormone target organs. Evolution & Development 5(1):67-75.

Markey CM, Luque EH, Munoz de Toro M, Sonnenschein C, Soto AM. 2001. In utero exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland. Biol Reprod 65(4):1215-1223.

Markey CM, Wadia PR, Rubin BS, Sonnenschein C, Soto AM. 2005. Long-term effects of fetal exposure to low doses of the xenoestrogen bisphenol-A in the female mouse genital tract. Biol Reprod 72(6):1344-1351.

Masuo Y, Morita M, Oka S, Ishido M. 2004. Motor hyperactivity caused by a deficit in dopaminergic neurons and the effects of endocrine disruptors: A study inspired by the physiological roles of PACAP in the brain. Regul Pept 123(1-3):225-234.

Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Sutoh C, Nakazawa K, Amano K, Sajiki J, Shimizu E. 2012. Effects of perinatal exposure to low dose of bisphenol A on anxiety like behavior and dopamine metabolites in brain. Prog Neuropsychopharmacol Biol Psychiatry 39(2):273-279.

Matsuda S, Saika S, Amano K, Shimizu E, Sajiki J. 2010. Changes in brain monoamine levels in neonatal rats exposed to bisphenol A at low doses. Chemosphere 78(7):894-906.

Miyagawa K, Narita M, Narita M, Akama H, Suzuki T. 2007. Memory impairment associated with a dysfunction of the hippocampal cholinergic system induced by prenatal and neonatal exposures to bisphenol-A. Neurosci Lett 418(3):236-241.

Miyawaki J, Sakayama K, Kato H, Yamamoto H, Masuno H. 2007. Perinatal and postnatal exposure to bisphenol a increases adipose tissue mass and serum cholesterol level in mice. Journal of Atherosclerosis and Thrombosis 14(5):245-252.

Moral R, Wang R, Russo IH, Lamartiniere CA, Pereira J, Russo J. 2008 Jan. Effect of prenatal exposure to the endocrine disruptor bisphenol A on mammary gland morphology and gene expression signature. J Endocrinol 196(1):101-12.

Munoz-de-Toro M, Markey C, Wadia PR, Luque EH, Rubin BS, Sonnenschein C, Soto AM. 2005. Perinatal exposure to bisphenol-A alters peripubertal mammary gland development in mice. Endocrinology 146(9):4138-4147.

Murray TJ, Maffini MV, Ucci AA, Sonnenschein C, Soto AM. 2007. Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure. Reprod Toxicol 23(3):383-390.

Nagel SC, vom Saal FS, Thayer KA, Dhar MG, Boechler M, Welshons WV. 1997. Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol. Environ Health Perspect 105(1):70-76.

Nah WH, Park MJ, Gye MC. 2011. Effects of early prepubertal exposure to bisphenol A on the onset of puberty, ovarian weights, and estrous cycle in female mice. Clin Exp Reprod Med 38(2):75-81.

Nakamura K, Itoh K, Dai H, Han L, Wang X, Kato S, Sugimoto T, Fushiki S. 2012. Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behavior. Brain Dev 34(1):57-63.

Nakamura K, Itoh K, Sugimoto T, Fushiki S. 2007. Prenatal exposure to bisphenol A affects adult murine neocortical structure. Neurosci Lett 420(2):100-105.

Nakamura K, Itoh K, Yaoi T, Fujiwara Y, Sugimoto T, Fushiki S. 2006. Murine neocortical histogenesis is perturbed by prenatal exposure to low doses of bisphenol A. J Neurosci Res 84(6):1197-1205.

Nanjappa MK, Simon L, Akingbemi BT. 2012. The industrial chemical bisphenol A (BPA) interferes with proliferative activity and development of steroidogenic capacity in rat Leydig cells. Biol Reprod 86(5):135, 1-12.

Negishi T, Kawasaki K, Suzaki S, Maeda H, Ishii Y, Kyuwa S, Kuroda Y, Yoshikawa Y. 2004. Behavioral alterations in response to fear-provoking stimuli and tranylcypromine induced by perinatal exposure to bisphenol A and nonylphenol in male rats. Environ Health Perspect 112:1159-1164.

Newbold RR, Jefferson WN, Padilla-Banks E. 2007. Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract. Reprod Toxicol 24(2):253-258.

Newbold RR, Jefferson WN, Padilla-Banks E. 2009. Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life. Environ Health Perspect 117(6):879-885.

Nikaido Y, Yoshizawa K, Danbara N, Tsujita-Kyutoku M, Yuri T, Uehara N, Tsubura A. 2004. Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspring. Reprod Toxicol 18(6):803-811.

Nishizawa H, Manabe N, Morita M, Sugimoto M, Imanishi S, Miyamoto H. 2003. Effects of in utero exposure to bisphenol A on expression of RARalpha and RXRalpha mRNAs in murine embryos. Journal of Reproduction & Development 49(6):539-545.

Nishizawa H, Morita M, Sugimoto M, Imanishi S, Manabe N. 2005. Effects of in utero exposure to bisphenol A on mRNA expression of arylhydrocarbon and retinoid receptors in murine embryos. Journal of Reproduction & Development 51(3):315-324.

Okada A, Kai O. 2008 Mar. Effects of estradiol-17beta and bisphenol A administered chronically to mice throughout pregnancy and lactation on the male pups’ reproductive system. Asian Journal of Androl 10(2):271-6.

Palanza P, Gioiosa L, vom Saal FS, Parmigiani S. 2008 Oct. Effects of developmental exposure to bisphenol A on brain and behavior in mice. Environ Res 108(2):150-7.

Palanza PL, Howdeshell KL, Parmigiani S, vom Saal FS. 2002. Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in mice. Environ Health Perspect 110 (suppl 3):415-422.

Poimenova A, Markaki E, Rahiotis C, Kitraki E. 2010 May 19. Corticosterone-regulated actions in the rat brain are affected by perinatal exposure to low dose of bisphenol A. Neuroscience 167(3):741-9.

Ramos JG, Varayoud J, Kass L, Rodriguez H, Costabel L, Munoz-De-Toro M, Luque EH. 2003. Bisphenol A induces both transient and permanent histofunctional alterations of the hypothalamic-pituitary-gonadal axis in prenatally exposed male rats. Endocrinology 144(7):3206-3215.

Ramos JG, Varayoud J, Sonnenschein C, Soto AM, Munoz de Toro M, Luque EH. 2001. Prenatal exposure to low doses of bisphenol A alters the periductal stroma and glandular cell function in the rat ventral prostate. Biol Reprod 65(4):1271-1277.

Rubin BS, Lenkowski JR, Schaeberle CM, Vandenberg LN, Ronsheim PM, Soto AM. 2006. Evidence of altered brain sexual differentiation in mice exposed perinatally to low, environmentally relevant levels of bisphenol A. Endocrinology 147(8):3681-3691.

Rubin BS, Murray MK, Damassa DA, King JC, Soto AM. 2001. Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels. Environ Health Perspect 109(7):675-680.

Ryan BC, Vandenbergh JG. 2006. Developmental exposure to environmental estrogens alters anxiety and spatial memory in female mice. Hormones & Behavior 50(1):85-93.

Salian S, Doshi T, Vanage G. 2009. Perinatal exposure of rats to Bisphenol A affects the fertility of male offspring. Life Sci 85(21-22):742-752.

Sato K, Matsuki N, Ohno Y, Nakazawa K. 2002. Effects of 17beta-estradiol and xenoestrogens on the neuronal survival in an organotypic hippocampal culture. Neuroendocrinology 76(4):223-234.

Schonfelder G, Friedrich K, Paul M, Chahoud I. 2004. Developmental effects of prenatal exposure to bisphenol A on the uterus of rat offspring. Neoplasia 6(5):584-594.

Signorile PG, Spugnini EP, Citro G, Viceconte R, Vincenzi B, Baldi F, Baldi A. 2012. Endocrine disruptors in utero cause ovarian damages linked to endometriosis. Front Biosci (Elite Ed) 4:1724-1730.

Signorile PG, Spugnini EP, Mita L, Mellone P, D’Avino A, Bianco M, Diano N, Caputo L, Rea F, Viceconte R, Portaccio M, Viggiano E, Citro G, Pierantoni R, Sica V, Vincenzi B, Mita DG, Baldi F, Baldi A. 2010. Pre-natal exposure of mice to bisphenol A elicits an endometriosis-like phenotype in female offspring. Gen Comp Endocrinol 168(3):318-325.

Smith CC, Taylor HS. 2007. Xenoestrogen exposure imprints expression of genes (Hoxa10) required for normal uterine development. FASEB J 21(1):239-246.

Somm E, Schwitzgebel VM, Toulotte A, Cederroth CR, Combescure C, Nef S, Aubert ML, Huppi PS. 2009. Perinatal exposure to bisphenol a alters early adipogenesis in the rat. Environ Health Perspect 117(10):1549-1555.

Susiarjo M, Hassold TJ, Freeman E, Hunt PA. 2007. Bisphenol A exposure in utero disrupts early oogenesis in the mouse. PLoS Genetics 3(1):63-70.

Takai Y, Tsutsumi O, Ikezuki Y, Hiroi H, Osuga Y, Momoeda M, Yano T, Taketani Y. 2000. Estrogen receptor-mediated effects of a xenoestrogen, bisphenol A, on preimplantation mouse embryos. Biochemical & Biophysical Research Communications 270(3):918-921.

Takai Y, Tsutsumi O, Ikezuki Y, Kamei Y, Osuga Y, Yano T, Taketan Y. 2001. Preimplantation exposure to bisphenol A advances postnatal development. Reprod Toxicol 15(1):71-74.

Talsness C, Fialkowski O, Gericke C, Merker H-J, Chahoud I. 2000. The effects of low and high doses of bisphenol A on the reproductive system of female and male rat offspring. Congenital Anomalies 40:S94-S107.

Tanabe N, Kimoto T, Kawato S. 2006. Rapid Ca2+ signaling induced by bisphenol A in cultured rat hippocampal neurons. Neuroendocrinology Letters 27(1-2):97-104.

Tang WY, Morey LM, Cheung YY, Birch L, Prins GS, Ho SM. 2012. Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate gland throughout life. Endocrinology 153(1):42-55.

Thuillier R, Wang Y, Culty M. 2003. Prenatal exposure to estrogenic compounds alters the expression pattern of platelet-derived growth factor receptors alpha and beta in neonatal rat testis: Identification of gonocytes as targets of estrogen exposure. Biol Reprod 68(3):867-880.

Timms BG, Howdeshell KL, Barton L, Bradley S, Richter CA, vom Saal FS. 2005. Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra. Proceedings of the National Academy of Sciences USA 102(19):7014-7019 and cover illustration.

Vandenberg LN, Maffini MV, Schaeberle CM, Ucci AA, Sonnenschein C, Rubin BS, Soto AM. 2008 Nov-Dec. Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 mice. Reprod Toxicol 26(3-4):210-9.

Vandenberg LN, Maffini MV, Wadia PR, Sonnenschein C, Rubin BS, Soto AM. 2007. Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland. Endocrinology 148(1):116-127.

Varayoud J, Ramos JG, Bosquiazzo VL, Lower M, Munoz-de-Toro M, Luque EH. 2011. Neonatal exposure to bisphenol A alters rat uterine implantation-associated gene expression and reduces the number of implantation sites. Endocrinology 152(3):1101-1111.

Viberg H, Fredriksson A, Buratovic S, Eriksson P. 2011. Dose-dependent behavioral disturbances after a single neonatal bisphenol A dose. Toxicology 290(2-3):187-194.

vom Saal FS, Cooke PS, Buchanan DL, Palanza P, Thayer KA, Nagel SC, Parmigiani S, Welshons WV. 1998. A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior. Toxicology & Industrial Health 14(1-2):239-260.

Weber Lozada K, Keri RA. 2011. Bisphenol A increases mammary cancer risk in two distinct mouse models of breast cancer. Biol Reprod 85(3):490-497.

Wolstenholme JT, Taylor JA, Shetty SR, Edwards M, Connelly JJ, Rissman EF. 2011. Gestational exposure to low dose bisphenol A alters social behavior in juvenile mice. PLoS One 6(9):e25448.

Xu X, Liu Y, Sadamatsu M, Tsutsumi S, Akaike M, Ushijima H, Kato N. 2007. Perinatal bisphenol A affects the behavior and SRC-1 expression of male pups but does not influence on the thyroid hormone receptors and its responsive gene. Neurosci Res 58(2):149-155.

Xu X, Tan L, Himi T, Sadamatsu M, Tsutsumi S, Akaike M, Kato N. 2011. Changed preference for sweet taste in adulthood induced by perinatal exposure to bisphenol A-A probable link to overweight and obesity. Neurotoxicol Teratol 33(4):458-463.

Xu XH, Zhang J, Wang YM, Ye YP, Luo QQ. 2010. Perinatal exposure to bisphenol-A impairs learning-memory by concomitant down-regulation of N-methyl-D-aspartate receptors of hippocampus in male offspring mice. Horm Behav 58(2):326-333.

Yaoi T, Itoh K, Nakamura K, Ogi H, Fujiwara Y, Fushiki S. 2008. Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A. Biochemical & Biophysical Research Communications 376(3):563-567.

Yokosuka M, Ohtani-Kaneko R, Yamashita K, Muraoka D, Kuroda Y, Watanabe C. 2008. Estrogen and environmental estrogenic chemicals exert developmental effects on rat hypothalamic neurons and glias. Toxicology in Vitro 22(1):1-9.

Yoshino S, Yamaki K, Li X, Sai T, Yanagisawa R, Takano H, Taneda S, Hayashi H, Mori Y. 2004. Prenatal exposure to bisphenol A up-regulates immune responses, including T helper 1 and T helper 2 responses, in mice. Immunology 112:489-495.

Zhang HQ, Zhang XF, Zhang LJ, Chao HH, Pan B, Feng YM, Li L, Sun XF, Shen W. 2012. Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes. Mol Biol Rep 39(5):5651-5657.

Zhang XF, Zhang LJ, Feng YN, Chen B, Feng YM, Liang GJ, Li L, Shen W. 2012. Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells. Mol Biol Rep 39(9):8621-8628.

Zhou R, Bai Y, Yang R, Zhu Y, Chi X, Li L, Chen L, Sokabe M, Chen L. 2011. Abnormal synaptic plasticity in basolateral amygdala may account for hyperactivity and attention-deficit in male rat exposed perinatally to low-dose bisphenol-A. Neuropharmacology 60(5):789-798.

Zoeller RT, Bansal R, Parris C. 2005. Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine and alters RC3/neurogranin expression in the developing rat brain. Endocrinology 146(2):607-612.

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Phthalates

Andrade AJ, Grande SW, Talsness CE, Gericke C, Grote K, Golombiewski A, Sterner-Kock A, Chahoud I. 2006. A dose response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): Reproductive effects on adult male offspring rats. Toxicology 228(1):85-97.

Andrade AJM, Grande SW, Talsness CE, Grote K, Chahoud I. 2006. A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): Non-monotonic dose-response and low dose effects on rat brain aromatase activity. Toxicology 227(3):185-192.

Andrade AJM, Grande SW, Talsness CE, Grote K, Golombiewski A, Sterner-Kock A, Chahoud I. 2006. A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): Effects on androgenic status, developmental landmarks and testicular histology in male offspring rats. Toxicology 225(1):64-74.

Ashby J, Tinwell H, Lefevre PA, Odum J, Paton D, Millward SW, Tittensor S, Brooks AN. 1997. Normal sexual development of rats exposed to butyl benzyl phthalate from conception to weaning. Regulatory Toxicology & Pharmacology 26(1 Part 1):102-118.

Do RP, Stahlhut RW, Ponzi D, Vom Saal FS, Taylor JA. 2012. Non-monotonic dose effects of in utero exposure to di(2-ethylhexyl) phthalate (DEHP) on testicular and serum testosterone and anogenital distance in male mouse fetuses. Reprod Toxicol 34(4):614-621.

Grande SW, Andrade AJM, Talsness CE, Grote K, Chahoud I. 2006. A dose-response study following in utero and lactational exposure to di(2-ethylhexyl)phthalate: Effects on female rat reproductive development. Toxicol Sci 91(1):247-254.

Hao C, Cheng X, Xia H, Ma X. 2012. The endocrine disruptor mono-(2-ethylhexyl) phthalate promotes adipocyte differentiation and induces obesity in mice. Biosci Rep 32(6):619-629.

Hoshi H, Ohtsuka T. 2009. Adult Rats Exposed to Low-Doses of Di-n-Butyl Phthalate During Gestation Exhibit Decreased Grooming Behavior. Bull Environ Contam Toxicol 83(1):62-66.

Ishido M, Masuo Y, Sayato-Suzuki J, Oka S, Niki E, Morita M. 2004 Oct. Dicyclohexylphthalate causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivity. J Neurochem 91(1):69-76.

Lehmann KP, Phillips S, Sar M, Foster PMD, Gaido KW. 2004. Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate. Toxicol Sci 81(1):60-68.

Lin Y, Wei J, Li Y, Chen J, Zhou Z, Song L, Wei Z, Lv Z, Chen X, Xia W, Xu S. 2011. Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat. Am J Physiol Endocrinol Metab 301(3):E527-E538.

Pocar P, Fiandanese N, Secchi C, Berrini A, Fischer B, Schmidt JS, Schaedlich K, Borromeo V. 2012. Exposure to di(2-ethyl-hexyl) phthalate (DEHP) in utero and during lactation causes long-term pituitary-gonadal axis disruption in male and female mouse offspring. Endocrinology 153(2):937-948.

Sabbieti MG, Agas D, Santoni G, Materazzi S, Menghi G, Marchetti L. 2009. Involvement of p53 in phthalate effects on mouse and rat osteoblasts. J Cell Biochem 107(2):316-327.

Schmidt JS, Schaedlich K, Fiandanese N, Pocar P, Fischer B. 2012. Effects of di(2-ethylhexyl) phthalate (DEHP) on female fertility and adipogenesis in C3H/N mice. Environ Health Perspect 120(8):1123-1129.

Sharpe RM, Fisher JS, Millar MM, Jobling S, Sumpter JP. 1995. Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production. Environ Health Perspect 103(12):1136-1143.

Sun W, Ban JB, Zhang N, Zu YK, Sun WX. 2012 May 19 (in press). Perinatal exposure to di-(2-ethylhexyl)-phthalate leads to cognitive dysfunction and phospho-tau level increase in aged rats. Environ Toxicol .

Wei Z, Song L, Wei J, Chen T, Chen J, Lin Y, Xia W, Xu B, Li X, Chen X, Li Y, Xu S. 2012. Maternal exposure to di-(2-ethylhexyl)phthalate alters kidney development through the renin-angiotensin system in offspring. Toxicol Lett 212(2):212-221.

Yanagisawa R, Takano H, Inoue K, Koike E, Sadakane K, Ichinose T. 2008. Effects of maternal exposure to di-(2-ethylhexyl) phthalate during fetal and/or neonatal periods on atopic dermatitis in male offspring. Environ Health Perspect 116(9):1136-1141.

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Dioxin

Abbott BD, Birnbaum LS. 1990. Rat embryonic palatal shelves respond to TCDD in organ-culture. Toxicol Appl Pharmacol 103(3):441-451.

Abbott BD, Held GA, Wood CR, Buckalew AR, Brown JG, Schmid J. 1999. AhR, ARNT, and CYP1A1 mRNA quantitation in cultured human embryonic palates exposed to TCDD and comparison with mouse palate in vivo and in culture. Toxicol Sci 47(1):62-75.

Abbott BD, Lin TM, Rasmussen NT, Albrecht RM, Schmid JE, Peterson RE. 2003. Lack of expression of EGF and TGF-alpha in the fetal mouse alters formation of prostatic epithelial buds and influences the response to TCDD. Toxicol Sci 76(2):427-436.

Adamsson A, Simanainen U, Viluksela M, Paranko J, Toppari J. 2009. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on foetal male rat steroidogenesis. Int J Androl 32(5):575-585.

Allgeier SH, Vezina CM, Lin TM, Moore RW, Silverstone AE, Mukai M, Gavalchin J, Cooke PS, Peterson RE. 2009. Estrogen signaling is not required for prostatic bud patterning or for its disruption by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 239(1):80-86.

Amin S, Moore RW, Peterson RE, Schantz SL. 2000. Gestational and lactational exposure to TCDD or coplanar PCBs alters adult expression of saccharin preference behavior in female rats. Neurotoxicology & Teratology 22(5):675-682.

Aragon AC, Kopf PG, Campen MJ, Huwe JK, Walker MK. 2008. In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: Effects on fetal and adult cardiac gene expression and adult cardiac and renal morphology. Toxicol Sci 101(2):321-330.

Bell DR, Clode S, Fan MQ, Fernandes A, Foster PMD, Jiang T, Loizou G, Macnicoll A, Miller BG, Rose M, Tran L, White S. 2007. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. I: No decrease in epididymal sperm count after a single acute dose. Toxicol Sci 99(1):214-223.

Bell DR, Clode S, Fan MQ, Fernandes A, Foster PMD, Jiang T, Loizou G, Macnicoll A, Miller BG, Rose M, Tran L, White S. 2007. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. II: Chronic dosing causes developmental delay. Toxicol Sci 99(1):224-233.

Bjerke DL, Brown TJ, MacLusky NJ, Hochberg RB, Peterson RE. 1994. Partial demasculinization and feminization of sex behavior in male rats by in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin is not associated with alterations in estrogen receptor binding or volumes of sexually differentiated brain nuclei. Toxicology & Applied Pharmacology 127(2):258-267.

Bjerke DL, Peterson RE. 1994. Reproductive toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male-rats - different effects of in utero versus lactational exposure. Toxicol Appl Pharmacol 127(2):241-249.

Bjerke DL, Sommer RJ, Moore RW, Peterson RE. 1994. Effects of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on responsiveness of the male rat reproductive system to testosterone stimulation in adulthood. Toxicol Appl Pharmacol 127(2):250-257.

Brown NM, Manzolillo PA, Zhang JX, Wang J, Lamartiniere CA. 1998. Prenatal TCDD and predisposition to mammary cancer in the rat. Carcinogenesis 19(9):1623-1629.

Bryant PL, Reid LM, Schmidt JE, Buckalew AR, Abbott BD. 2001. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on fetal mouse urinary tract epithelium in vitro. Toxicology 162(1):23-34.

Chaffin CL, Brogan RS, Peterson RE, Hutz RJ, Wehrenberg WB. 1996. Modulation of growth axis gene expression by in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the weanling Holtzman rat. Endocr J 5:129-134.

Chaffin CL, Peterson RE, Hutz RJ. 1996. In utero and lactational exposure of female Holtzman rats to 2,3,7,8- tetrachlorodibenzo-p-dioxin: modulation of the estrogen signal. Biol Reprod 55(1):62-67.

Chaffin CL, Trewin AL, Watanabe G, Taya K, Hutz RJ. 1997. Alterations to the pituitary-gonadal axis in the peripubertal female rat exposed in utero and through lactatoin to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biol Reprod 56(6):1498-1502.

Clements RJ, Lawrence RC, Blank JL. 2009. Effects of intrauterine 2,3,7,8-tetrachlorodibenzo-p-dioxin on the development and function of the gonadotrophin releasing hormone neuronal system in the male rat. Reprod Toxicol 28(1):38-45.

Collins LL, Williamson MA, Thompson BD, Dever DP, Gasiewicz TA, Opanashuk LA. 2008. 2,3,7,8-Tetracholorodibenzo-p-dioxin exposure disrupts granule neuron precursor maturation in the developing mouse cerebellum. Toxicol Sci 103(1):125-136.

Cooke GM, Price CA, Oko RJ. 1998. Effects of in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on serum androgens and steroidogenic enzyme activities in the male rat reproductive tract. J Steroid Biochem Mol Biol 67(4):347-354.

Couture LA, Harris MW, Birnbaum LS. 1990 Jul. Characterization of the peak period of sensitivity for the induction of hydronephrosis in C57BL/6N mice following exposure to 2,3,7, 8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol 15(1):142-50.

Couture-Haws L, Harris MW, Lockhart AC, Birnbaum LS. 1991. Evaluation of the persistence of hydronephrosis induced in mice following in utero and/or lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 107(3):402-412.

Cummings AM, Hedge JM, Birnbaum LS. 1999. Effect of prenatal exposure to TCDD on the promotion of endometriotic lesion growth by TCDD in adult female rats and mice. Toxicol Sci 52(1):45-49.

Dienhart MK, Sommer RJ, Peterson RE, Hirshfield AN, Silbergeld EK. 2000. Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces developmental defects in the rat vagina. Toxicol Sci 56(1):141-149.

Faqi AS, Chahoud I. 1998. Antiestrogenic effects of low doses of 2,3,7,8-TCDD in offspring of female rats exposed throughout pregnancy and lactation. Bulletin of Environmental Contamination & Toxicology 61(4):462-469.

Faqi AS, Dalsenter PR, Merker HJ, Chahoud I. 1998. Reproductive toxicity and tissue concentrations of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male offspring rats exposed throughout pregnancy and lactation. Toxicology & Applied Pharmacology 150(2):383-392.

Fenton SE, Hamm JT, Birnbaum LS, Youngblood GL. 2002. Persistent abnormalities in the rat mammary gland following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Sci 67(1):63-74.

Finnila MA, Zioupos P, Herlin M, Miettinen HM, Simanainen U, Hakansson H, Tuukkanen J, Viluksela M, Jamsa T. 2010. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on bone material properties. J Biomech 43(6):1097-1103.

Flaws JA, Sommer RJ, Silbergeld EK, Peterson RE, Hirshfield AN. 1997. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces genital dysmorphogenesis in the female rat. Toxicology & Applied Pharmacology 147(2):351-362.

Fritz WA, Lin TM, Moore RW, Cooke PS, Peterson RE. 2005. In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effects on the prostate and its response to castration in senescent C57BL/6J mice. Toxicol Sci 86(2):387-395.

Gehrs BC, Riddle MM, Williams WC, Smialowicz RJ. 1997. Alterations in the developing immune system of the F344 rat after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin .I. Effects on the fetus and the neonate. Toxicology 122(3):219-228.

Gehrs BC, Riddle MM, Williams WC, Smialowicz RJ. 1997. Alterations in the developing immune system of the F344 rat after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin .II. Effects on the pup and the adult. Toxicology 122(3):229-240.

Gehrs BC, Smialowicz RJ. 1999. Persistent suppression of delayed-type hypersensitivity in adult F344 rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology 134(1):79-88.

Gierthy JF, Silkworth JB, Tassinari M, Stein GS, Lian JB. 1994. 2,3,7,8-tetrachlorodibenzo-p-dioxin inhibits differentiation of normal diploid rat osteoblasts in vitro. J Cell Biochem 54(2):231-238.

Gordon CJ, Gray LE, Monteiro-Riviere NA, Miller DB. 1995. Temperature regulation and metabolism in rats exposed perinatally to dioxin - Permanent change in regulated body temperature. Toxicology & Applied Pharmacology 133(1):172-176.

Gordon CJ, Miller DB. 1998. Thermoregulation in rats exposed perinatally to dioxin - core temperature stability to altered ambient temperature, behavioral thermoregulation, and febrile response to lipopolysaccharide. Journal of Toxicology & Environmental Health. Part A 54(8):647-662.

Gray LE Jr., Ostby JS, Kelce WR. 1997. A dose-response analysis of the reproductive effects of a single gestational dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male Long Evans Hooded rat offspring. Toxicology & Applied Pharmacology 146(1):11-20.

Gray LE Jr., Ostby JS. 1995. In utero 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters reproductive morphology and function in female rat offspring. Toxicology & Applied Pharmacology 133(2):285-294.

Gray LE, Kelce WR, Monosson E, Ostby JS, Birnbaum LS. 1995. Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: Reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicology & Applied Pharmacology 131(1):108-118.

Gray LE, Wolf C, Mann P, Ostby JS. 1997. In utero exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive development of female Long Evans Hooded rat offspring. Toxicology & Applied Pharmacology 146(2):237-244.

Haavisto T, Nurmela K, Pohjanvirta R, Huuskonen H, El-Gehani F, Paranko J. 2001. Prenatal testosterone and luteinizing hormone levels in male rats exposed during pregnancy to 2,3,7,8-tetrachlorodibenzo-p-dioxin and diethylstilbestrol. Mol Cell Endocrinol 178(1-2):169-179.

Haavisto TE, Myllymaki SA, Adamsson NA, Brokken LJS, Viluksela M, Toppari J, Paranko J. 2006. The effects of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on testicular steroidogenesis in infantile male rats. Int J Androl 29(2):313-322.

Hamm JT, Sparrow BR, Wolf D, Birnbaum LS. 2000. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters postnatal development of seminal vesicle epithelium. Toxicol Sci 54(2):424-430.

Hays LE, Carpenter CD, Petersen SL. 2002. Evidence that GABAergic neurons in the preoptic area of the brain are targets of 2,3,7,8-tetrachloro-p-dioxin during development. Environ Health Perspect 110 (suppl 3):369-376.

Heimler I, Trewin AL, Chaffin CL, Rawlins RG, Hutz RJ. 1998. Modulation of ovarian follicle maturation and effects on apoptotic cell death in Holtzman rats exposed to 2,3,7,8-tetrachlorodtbenzo-p-dioxin (TCDD) in utero and lactationally. Reprod Toxicol 12(1):69-73.

Hogaboam JP, Moore AJ, Lawrence BP. 2008 Mar. The aryl hydrocarbon receptor affects distinct tissue compartments during ontogeny of the immune system. Toxicol Sci 102(1):160-70.

Hojo R, Stern S, Zareba G, Markowski VP, Cox C, Kost JT, Weiss B. 2002. Sexually dimorphic behavioral responses to prenatal dioxin exposure. Environ Health Perspect 110(3):247-254.

Hojo R, Zareba G, Kai JW, Baggs RB, Weiss B. 2006. Sex-specific alterations of cerebral cortical cell size in rats exposed prenatally to dioxin. J Appl Toxicol 26(1):25-34.

Holladay SD, Lindstrom P, Blaylock BL, Comment CE, Germolec DR, Heindell JJ, Luster MI. 1991. Perinatal thymocyte antigen expression and postnatal immune development altered by gestational exposure to tetrachlorodibenzo-p-dioxin (TCDD). Teratology 44(4):385-393.

Hood DB, Woods L, Brown L, Johnson S, Ebner FF. 2006. Gestational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure effects on sensory cortex function. Neurotoxicology 27(6):1032-1042.

Huang L, Huang R, Ran XR, Liu HY, Zhang Y, Dai LJ, Li B. 2011. Three-generation experiment showed female C57BL/6J mice drink drainage canal water containing low level of TCDD-like activity causing high pup mortality. J Toxicol Sci 36(6):713-724.

Hurst CH, Abbott B, Schmid JE, Birnbaum LS. 2002. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) disrupts early morphogenetic events that form the lower reproductive tract in female rat fetuses. Toxicol Sci 65(1):87-98.

Hutt KJ, Shi Z, Albertini DF, Petroff BK. 2008. The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts morphogenesis of the rat pre-implantation embryo. BMC Dev Biol 8:1.

Iba MM, Fung J. 2001. Pulmonary CYP1A1 and CYP1A2 levels and activities in adult male and female offspring of rats exposed during gestation and lactation to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem Pharmacol 62(5):617-626.

Ikeda M, Inukai N, Mitsui T, Sone H, Yonemoto J, Tohyama C, Tomita T. 2002. Changes in fetal brain aromatase following in utero 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in rats. Environmental Toxicology & Pharmacology 11(1):1-7.

Ikeda M, Mitsui T, Setani K, Tamura M, Kakeyama M, Sone H, Tohyama C, Tomita T. 2005. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats disrupts brain sexual differentiation. Toxicology & Applied Pharmacology 205(1):98-105.

Ikeda M, Tamura M, Yamashita J, Suzuki C, Tomita T. 2005. Repeated in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure affects male gonads in offspring, leading to sex ratio changes in F-2 progeny. Toxicology & Applied Pharmacology 206(3):351-355.

Ishizuka M, Yonemoto J, Zaha H, Tohyama C, Sone H. 2003. Perinatal exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin alters sex-dependent expression of hepatic CYP2C11. J Biochem Mol Toxicol 17(5):278-285.

Jin MH, Hong CH, Lee HY, Kang HJ, Han SW. 2010. Toxic effects of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on development of male reproductive system: involvement of antioxidants, oxidants, and p53 protein. Environ Toxicol 25(1):1-8.

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Kakeyama M, Sone H, Miyabara Y, Tohyama C. 2003. Perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters activity-dependent expression of BDNF mRNA in the neocortex and male rat sexual behavior in adulthood. Neurotoxicology 24(2):207-217.

Kakeyama M, Sone H, Tohyama C. 2001. Changes in expression of NMDA receptor subunit mRNA by perinatal exposure to dioxin. Neuroreport 12(18):4009-4012.

Kattainen H, Tuukkanen J, Simanainen U, Tuomisto JT, Kovero O, Lukinmaa PL, Alaluusua S, Tuomisto J, Viluksela M. 2001. In utero/lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure impairs molar tooth development in rats. Toxicology & Applied Pharmacology 174(3):216-224.

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Keller JM, Huang JC, Huet-Hudson Y, Leamy LJ. 2007. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on molar and mandible traits in congenic mice: A test of the role of the Ahr locus. Toxicology 242(1-3):52-62.

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Koga T, Ishida T, Takeda T, Ishii Y, Uchi H, Tsukimori K, Yamamoto M, Himeno M, Furue M, Yamada H. 2012. Restoration of dioxin-induced damage to fetal steroidogenesis and gonadotropin formation by maternal co-treatment with alpha-lipoic acid. PLoS One 7(7):e40322.

Korte M, Stahlmann R, Neubert D. 1990. Induction of hepatic monooxygenases in female rats and offspring in correlation with TCDD tissue concentrations after single treatment during pregnancy. Chemosphere 20(7-9):1193-1198.

Korte M, Stahlmann R, Thiel R, Nagao T, Chahoud I, Vanloveren H, Vos JG, Neubert D. 1991. Resistance to trichinella-spiralis infection, induction of hepatic monooxygenases, and concentrations in thymus and liver in rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemosphere 23(11-12):1845-1854.

Kransler KM, Tonucci DA, Mcgarrigle BP, Napoli JL, Olson JR. 2007. Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters retinoid homeostasis in maternal and perinatal tissues of the Holtzman rat. Toxicol Appl Pharmacol 224(1):29-38.

Kuchiiwa S, Cheng SB, Nagatomo I, Akasaki Y, Uchida M, Tominaga M, Hashiguchi W, Kuchiiwa T. 2002. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin decreases serotonin-immunoreactive neurons in raphe nuclei of male mouse offspring. Neurosci Lett 317(2):73-76.

La Merrill M, Harper R, Birnbaum LS, Cardiff RD, Threadgill DW. 2010 May. Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice. Environ Health Perspect 118(5):596-601.

La Merrill M, Kuruvilla BS, Pomp D, Birnbaum LS, Threadgill DW. 2009. Dietary fat alters body composition, mammary development, and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptors. Environ Health Perspect 117(9):1414-1419.

Lai ZW, Fiore NC, Gasiewicz TA, Silverstone AE. 1998. 2,3,7,8-tetrachlorodibenzo-p-dioxin and diethylstilbestrol affect thymocytes at different stages of development in fetal thymus organ culture. Toxicology & Applied Pharmacology 149(2):167-177.

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Lewis BC, Hudgins S, Lewis A, Schorr K, Sommer R, Peterson RE, Flaws JA, Furth PA. 2001. In utero and lactational treatment with 2,3,7,8-tetrachlorodibenzo-p- dioxin impairs mammary gland differentiation but does not block the response to exogenous estrogen in the postpubertal female rat. Toxicol Sci 62(1):46-53.

Lin TM, Ko K, Moore RW, Buchanan DL, Cooke PS, Peterson RE. 2001. Role of the aryl hydrocarbon receptor in the development of control and 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed male mice. Journal of Toxicology and Environmental Health-Part a 64(4):327-342.

Lin TM, Rasmussen NT, Moore RW, Albrecht RM, Peterson RE. 2003. Region-specific inhibition of prostatic epithelial bud formation in the urogenital sinus of C57BL/6 mice exposed in utero to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 76(1):171-181.

Lin TM, Simanainen U, Moore RW, Peterson RE. 2002. Critical windows of vulnerability for effects of 2,3,7,8- tetrachlorodibenzo-p-dioxin on prostate and seminal vesicle development in C57BL/6 mice. Toxicol Sci 69(1):202-209.

Loeffler IK, Peterson RE. 1999. Interactive effects of TCDD and p,p ’-DDE on male reproductive tract development in in utero and lactationally exposed rats. Toxicology & Applied Pharmacology 154(1):28-39.

Luster MI, Boorman GA, Dean JH, Harris MW, Luebke RW, Padarathsingh ML, Moore JA. 1980. Examination of bone marrow, immunologic parameters and host susceptibility following pre- and postnatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Int J Immunopharmacol 2(4):301-10.

Luster MI, Holladay SD, Blaylock BL, Germolec DR, Clark GC, Comment CE, Heindel JJ, Rosenthal GJ. 1992. TCDD inhibits murine thymocyte and B lymphocyte maturation. Chemosphere 25(1-2):115-118.

Mably TA, Bjerke DL, Moore RW, Gendron-Fitzpatrick A, Peterson RE. 1992. In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 3. Effects on spermatogenesis and reproductive capability. Toxicology & Applied Pharmacology 114(1):118-126.

Mably TA, Moore RW, Goy RW, Peterson RE. 1992. In utero and lactational exposure of male-rats to 2,3,7,8-tetrachlorodibenzo-para-dioxin. 2. Effects on sexual-behavior and the regulation of luteinizing-hormone secretion in adulthood. Toxicol Appl Pharmacol 114(1):108-117.

Mably TA, Moore RW, Peterson RE. 1992. In utero and lactational exposure of male-rats to 2,3,7,8-tetrachlorodibenzo-para-dioxin. 1. Effects on androgenic status. Toxicol Appl Pharmacol 114(1):97-107.

Magre S, Rebourcet D, Ishaq M, Wargnier R, Debard C, Meugnier E, Vidal H, Cohen-Tannoudji J, Le Magueresse-Battistoni B. 2012. Gender differences in transcriptional signature of developing rat testes and ovaries following embryonic exposure to 2,3,7,8-TCDD. PLoS One 7(7):e40306.

Markowski VP, Cox C, Preston R, Weiss B. 2002. Impaired cued delayed alternation behavior in adult rat offspring following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on gestation day 15. Neurotoxicology & Teratology 24(2):209-218.

Markowski VP, Zareba G, Stern S, Cox C, Weiss B. 2001. Altered operant responding for motor reinforcement and the determination of benchmark doses following perinatal exposure to low-level 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ Health Perspect 109(6):1-7.

Matsumoto Y, Ishida T, Takeda T, Koga T, Fujii M, Ishii Y, Fujimura Y, Miura D, Wariishi H, Yamada H. 2010. Maternal exposure to dioxin reduces hypothalamic but not pituitary metabolome in fetal rats: a possible mechanism for a fetus-specific reduction in steroidogenesis. J Toxicol Sci 35(3):365-373.

Miettinen HM, Alaluusua S, Tuomisto J, Viluksela M. 2002. Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: The role of exposure time. Toxicol Appl Pharmacol 184(1):57-66.

Miettinen HM, Huuskonen H, Partanen AM, Miettinen P, Tuomisto JT, Pohjanvirta R, Tuomisto J. 2004. Effects of epidermal growth factor receptor deficiency and 2,3,7,8-tetrachlor.odibenzo-p-dioxin on fetal development in mice. Toxicol Lett 150(3):285-291.

Miettinen HM, Pulkkinen P, Jamsa T, Koistinen J, Simanainen U, Tuomisto J, Tuukkanen J, Viluksela M. 2005. Effects of in utero and lactational TCDD exposure on bone development in differentially sensitive rat lines. Toxicol Sci 85(2):1003-1012.

Miettinen HM, Sorvari R, Alaluusua S, Murtomaa M, Tuukkanen J, Viluksela M. 2006. The effect of perinatal TCDD exposure on caries susceptibility in rats. Toxicol Sci 91(2):568-575.

Mitsui T, Sugiyama N, Maeda S, Tohyama C, Arita J. 2006. Perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin suppresses contextual fear conditioning-accompanied activation of cyclic AMP response element-binding protein in the hippocampal CA1 region of male rats. Neurosci Lett 398(3):206-210.

Mitsui T, Taniguchi N, Kawasaki N, Kagami Y, Arita J. 2011. Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces expression of the chemokine genes Cxcl4 and Cxcl7 in the perinatal mouse brain. J Appl Toxicol 31(3):279-284.

Murray FJ, Smith FA, Nitschke KD, Humiston CG, Kociba RJ, Schwetz BA. 1979 Sep 15. Three-generation reproduction study of rats given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the diet. Toxicol Appl Pharmacol 50(2):241-52.

Mustafa A, Holladay SD, Witonsky S, Sponenberg DP, Karpuzoglu E, Gogal RM Jr. 2011. A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice. Toxicology 290(2-3):156-168.

Mutoh J, Taketoh J, Okamura K, Kagawa T, Ishida T, Ishii Y, Yamada H. 2006. Fetal pituitary gonadotropin as an initial target of dioxin in its impairment of cholesterol transportation and steroidogenesis in rats. Endocrinology 147(2):927-936.

Myllymaki SA, Haavisto TE, Brokken LJS, Viluksela M, Toppari J, Paranko J. 2005. In utero and lactational exposure to TCDD; Steroidogenic outcomes differ in male and female rat pups. Toxicol Sci 88(2):534-544.

Nayyar T, Zawia NH, Hood DB. 2002. Transplacental effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the temporal modulation of Sp1 DNA binding in the developing cerebral cortex and cerebellum. Exp Toxicol Pathol 53(6):461-468.

Neubert R, Stahlmann R, Korte M, Vanloveren H, Vos JG, Golor G, Webb JR, Helge H, Neubert D. 1993. Effects of small doses of dioxins on the immune-system of marmosets and rats. Ann N Y Acad Sci 685:662-686.

Nishijo M, Kuriwaki JI, Hori E, Tawara K, Nakagawa H, Nishijo H. 2007. Effects of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on fetal brain growth and motor and behavioral development in offspring rats. Toxicol Lett 173(1):41-47.

Nishimura N, Yonemoto J, Miyabara Y, Sato M, Tohyama C. 2003. Rat thyroid hyperplasia induced by gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Endocrinology 144(5):2075-2083.

Nishimura N, Yonemoto J, Nishimura H, Ikushiro S, Tohyama C. 2005. Disruption of thyroid hormone homeostasis at weaning of holtzman rats by lactational but not in utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 85(1):607-614.

Nohara K, Fujimaki H, Tsukumo S, Ushio H, Miyabara Y, Kijima M, Tohyama C, Yonemoto J. 2000. The effects of perinatal exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin on immune organs in rats. Toxicology 154(1-3):123-133.

Ohsako S, Miyabara Y, Nishimura N, Kurosawa S, Sakaue M, Ishimura R, Sato M, Takeda K, Aoki Y, Sone H, Tohyama C, Yonemoto J. 2001. Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: dose-dependent increase of mRNA levels of 5 alpha-reductase type 2 in contrast to decrease of androgen receptor in the pubertal ventral prostate. Toxicol Sci 60(1):132-143.

Ohsako S, Miyabara Y, Sakaue M, Ishimura R, Kakeyama M, Izumi H, Yonemoto J, Tohyama C. 2002. Developmental stage-specific effects of perinatal 2,3,7,8- tetrachlorodibenzo-p-dioxin exposure on reproductive organs of male rat offspring. Toxicol Sci 66(2):283-292.

Ohyama K, Ohta M, Sano T, Sato K, Nakagomi Y, Shimura Y, Yamano Y. 2007. Maternal exposure of low dose of TCDD modulates the expression of estrogen receptor subunits of male gonads in offspring. J Vet Med Sci 69(6):619-625.

Pesonen SA, Haavisto TE, Viluksela M, Toppari J, Paranko J. 2006. Effects of in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on rat follicular steroidogenesis. Reprod Toxicol 22(3):521-528.

Peterson RE, Mably TA, Moore RW, Goy RW. 1992. In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin: Effects on sexual behavior and the regulation of luteinizing hormone secretion in adulthood. Chemosphere 25(1-2):157-160.

Powers BE, Lin TM, Vanka A, Peterson RE, Juraska JM, Schantz SL. 2005. Tetrachlorodibenzo-p-dioxin exposure alters radial arm maze performance and hippocampal morphology in female AhR(+/-) mice. Genes Brain and Behavior 4(1):51-59.

Rebourcet D, Odet F, Verot A, Combe E, Meugnier E, Pesenti S, Leduque P, Dechaud H, Magre S, Le Magueresse-Battistoni B. 2010. The effects of an in utero exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin on male reproductive function: identification of Ccl5 as a potential marker. Int J Androl 33(2):413-424.

Roman BL, Peterson RE. 1998. In utero and lactational exposure of the male rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs prostate development: 1 - Effects on gene expression. Toxicology & Applied Pharmacology 150(2):240-253.

Roman BL, Sommer RJ, Shinomiya K, Peterson RE. 1995. In utero and lactational exposure of the male rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin - Impaired prostate growth and development without inhibited androgen production. Toxicology & Applied Pharmacology 134(2):241-250.

Roman BL, Timms BG, Prins GS, Peterson RE. 1998. In utero and lactational exposure of the male rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs prostate development: 2 - Effects on growth and cytodifferentiation. Toxicology & Applied Pharmacology 150(2):254-270.

Salisbury TB, Marcinkiewicz JL. 2002. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran reduces growth disrupts reproductive parameters in female rats. Biol Reprod 66(6):1621-1626.

Schantz SL, Seo BW, Moshtaghian J, Peterson RE, Moore RW. 1996. Effects of gestational and lactational exposure to TCDD or coplanar PCBs on spatial learning. Neurotoxicology & Teratology 18(3):305-313.

Schwanekamp JA, Sartor MA, Karyala S, Halbleib D, Medvedovic M, Tomlinson CR. 2006. Genome-wide analyses show that nuclear and cytoplasmic RNA levels are differentially affected by dioxin. Biochimica Et Biophysica Acta-Gene Structure and Expression 1759(8-9):388-402.

Seo BW, Li MH, Hansen LG, Moore RW, Peterson RE, Schantz SL. 1995. Effects of gestational and lactational exposure to coplanar polychlorinated biphenyl (PCB) congeners or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thyroid hormone concentrations in weanling rats. Toxicol Lett 78(3):253-262.

Seo BW, Powers BE, Widholm JJ, Schantz SL. 2000. Radial arm maze performance in rats following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Neurotoxicology & Teratology 22(4):511-519.

Seo BW, Sparks AJ, Medora K, Amin S, Schantz SL. 1999. Learning and memory in rats gestationally and lactationally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Neurotoxicology & Teratology 21(3):231-239.

Shi ZQ, Valdez KE, Ting AY, Franczak A, Gum SL, Petroff BK. 2007. Ovarian endocrine disruption underlies premature reproductive senescence following environmentally relevant chronic exposure to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biol Reprod 76(2):198-202.

Slezak BP, Hamm JT, Reyna J, Hurst CH, Birnbaum LS. 2002. TCDD-mediated oxidative stress in male rat pups following perinatal exposure. J Biochem Mol Toxicol 16(2):49-52.

Sommer RJ, Ippolito DL, Peterson RE. 1996. In utero and lactational exposure of the male Holtzman rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin - Decreased epididymal and ejaculated sperm numbers without alterations in sperm transit rate. Toxicology & Applied Pharmacology 140(1):146-153.

Sommer RJ, Sojka KM, Pollenz RS, Cooke PS, Peterson RE. 1999. Ah receptor and arnt protein and mRNA concentrations in rat prostate: Effects of stage of development and 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment. Toxicology & Applied Pharmacology 155(2):177-189.

Sugita-Konishi Y, Kobayashi K, Naito H, Miura K, Suzuki Y. 2003. Effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on the susceptibility to Listeria infection. Biosci Biotechnol Biochem 67(1):89-93.

Svensson C, Silverstone AE, Lai ZW, Lundberg K. 2002. Dioxin-induced adseverin expression in the mouse thymus is strictly regulated and dependent on the aryl hydrocarbon receptor. Biochem Biophys Res Commun 291(5):1194-1200.

Takeda T, Fujii M, Taura J, Ishii Y, Yamada H. 2012. Dioxin silences gonadotropin expression in perinatal pups by inducing histone deacetylases: a new insight into the mechanism for the imprinting of sexual immaturity by dioxin. J Biol Chem 287(22):18440-18450.

Takeda T, Matsumoto Y, Koga T, Mutoh J, Nishimura Y, Shimazoe T, Ishii Y, Ishida T, Yamada H. 2009. Maternal exposure to dioxin disrupts gonadotropin production in fetal rats and imprints defects in sexual behavior. J Pharmacol Exp Ther 329(3):1091-1099.

Taketoh J, Mutoh J, Takeda T, Ogishima T, Takeda S, Ishii Y, Ishida T, Yamada H. 2007. Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary. Life Sci 80(14):1259-1267.

Tanaka J, Yonemoto J, Zaha H, Kiyama R, Sone H. 2007. Estrogen-responsive genes newly found to be modified by TCDD exposure in human cell lines and mouse systems. Molecular & Cellular Endocrinology 272(1-2):38-49.

Thackaberry EA, Jiang Z, Johnson CD, Ramos KS, Walker MK. 2005a. Toxicogenomic profile of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the murine fetal heart: modulation of cell cycle and extracellular matrix genes. Toxicol Sci 88(1):231-41.

Thackaberry EA, Nunez BA, Ivnitski-Steele ID, Friggins M, Walker MK. 2005b. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on murine heart development: alteration in fetal and postnatal cardiac growth, and postnatal cardiac chronotropy. Toxicol Sci 88(1):242-9.

Theobald HM, Roman BL, Lin TM, Ohtani S, Chen SW, Peterson RE. 2000. 2,3,7,8-tetrachlorodibenzo-p-dioxin inhibits luminal cell differentiation and androgen responsiveness of the ventral prostate without inhibiting prostatic 5alpha-dihydrotestosterone formation or testicular androgen production in rat offspring. Toxicol Sci 58(2):324-338.

Thiel R, Koch E, Ulbrich B, Chahoud I. 1994. Peri- and postnatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin - effects on physiological development, reflexes, locomotor activity and learning behaviour in Wistar rats. Arch Toxicol 69(2):79-86.

Thiel R, Korte M, Chahoud I, Neubert D. 1992. Locomotor-activity and postnatal-development of rats after exposure to 2,3,7,8-TCDD during the late fetal and early postnatal-period. Chemosphere 25(7-10):1227-1231.

Timms BG, Peterson RE, vom Saal FS. 2002. 2,3,7,8-tetrachlorodibenzo-p-dioxin interacts with endogenous estradiol to disrupt prostate gland morphogenesis in male rat fetuses. Toxicol Sci 67(2):264-274.

Tomasini MC, Beggiato S, Ferraro L, Tanganelli S, Marani L, Lorenzini L, Antonelli T. 2012. Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin produces alterations in cortical neuron development and a long-term dysfunction of glutamate transmission in rat cerebral cortex. Neurochem Int 61(5):759-766.

Tonack S, Kind K, Thompson JG, Wobus AM, Fischer B, Santos AN. 2007. Dioxin affects glucose transport via the arylhydrocarbon receptor signal cascade in pluripotent embryonic carcinoma cells. Endocrinology 148(12):5902-5912.

Vezina CM, Hardin HA, Moore RW, Allgeier SH, Peterson RE. 2010. 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits fibroblast growth factor 10-induced prostatic bud formation in mouse urogenital sinus. Toxicol Sci 113(1):198-206.

Walker DB, Williams WC, Copeland CB, Smialowicz RJ. 2004. Persistent suppression of contact hypersensitivity, and altered T-cell parameters in F344 rats exposed perinatally to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicology 197(1):57-66.

Weinstein DA, Gogal RM Jr, Mustafa A, Prater MR, Holladay SD. 2008. Mid-gestation exposure of C57BL/6 mice to 2,3,7,8-tetrachlorodibenzo-p-dioxin causes postnatal morphologic changes in the spleen and liver. Toxicol Pathol 36(5):705-713.

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Wu Q, Ohsako S, Ishimura R, Suzuki JS, Tohyama C. 2004. Exposure of mouse preimplantation embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the methylation status of imprinted genes H19 and Igf2. Biol Reprod 70(6):1790-1797.

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Chlorpyrifos

Abou-Donia MB, Khan WA, Dechkovskaia AM, Goldstein LB, Bullman SL, Abdel-Rahman A. 2006. In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats. Arch Toxicol 80(9):620-631.

Aldridge JE, Levin ED, Seidler FJ, Slotkin TA. 2005. Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. Environ Health Perspect 113(5):527-531.

Aldridge JE, Meyer A, Seidler FJ, Slotkin TA. 2005. Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure. Environ Health Perspect 113(8):1027-1031.

Aldridge JE, Meyer A, Seidler FJ, Slotkin TA. 2005. Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. Toxicology & Applied Pharmacology 203(2):132-144.

Aldridge JE, Seidler FJ, Meyer A, Thillai I, Slotkin TA. 2003. Serotonergic systems targeted by developmental exposure to chlorpyrifos: Effects during different critical periods. Environ Health Perspect 111(14):1736-1743.

Aldridge JE, Seidler FJ, Slotkin TA. 2004. Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: Critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environ Health Perspect 112(2):148-155.

Auman JT, Seidler FJ, Slotkin TA. 2000. Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity. Developmental Brain Research 121(1):19-27.

Braquenier JB, Quertemont E, Tirelli E, Plumier JC. 2010 Mar-2010 Apr 30. Anxiety in adult female mice following perinatal exposure to chlorpyrifos. Neurotoxicol Teratol 32(2):234-239.

Campbell CG, Seidler FJ, Slotkin TA. 1997. Chlorpyrifos interferes with cell development in rat brain regions. Brain Res Bull 43(2):179-189.

Carr RL, Borazjani A, Ross MK. 2011. Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. Toxicol Sci 122(1):112-120.

Chen XP, Chen WZ, Wang FS, Liu JX. 2012. Selective cognitive impairments are related to selective hippocampus and prefrontal cortex deficits after prenatal chlorpyrifos exposure. Brain Res 1474:19-28.

Chen XP, Wang X, Dong JY. 2011. Different reaction patterns of dopamine content to prenatal exposure to chlorpyrifos in different periods. J Appl Toxicol 31(4):355-359.

Dam K, Garcia SJ, Seidler FJ, Slotkin TA. 1999. Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways. Developmental Brain Research 116(1):9-20.

Dam K, Seidler FJ, Slotkin TA. 1998. Developmental neurotoxicity of chlorpyrifos: delayed targeting of DNA synthesis after repeated administration. Developmental Brain Research 108(1-2):39-45.

Dam K, Seidler FJ, Slotkin TA. 2000. Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity. Developmental Brain Research 121(2):179-187.

Dam K, Seidler FJ, Slotkin TA. 2003. Transcriptional biomarkers distinguish between vulnerable periods for developmental neurotoxicity of chlorpyrifos: Implications for toxicogenomics. Brain Res Bull 59(4):261-265.

De Angelis S, Tassinari R, Maranghi F, Eusepi A, Di Virgilio A, Chiarotti F, Ricceri L, Venerosi Pesciolini A, Gilardi E, Moracci G, Calamandrei G, Olivieri A, Mantovani A. 2009. Developmental exposure to chlorpyrifos induces alterations in thyroid and thyroid hormone levels without other toxicity signs in CD-1 mice. Toxicol Sci 108(2):311-319.

Garcia SJ, Seidler FJ, Qiao D, Slotkin TA. 2002. Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein. Brain Res Dev Brain Res 133(2):151-161.

Garcia SJ, Seidler FJ, Slotkin TA. 2003. Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: Effects on neurospecific proteins indicate changing vulnerabilities. Environ Health Perspect 111(3):297-304.

Greenlee AR, Ellis TM, Berg RL. 2004. Low-dose agrochemicals and lawn-care pesticides induce developmental toxicity in murine preimplantation embryos. Environ Health Perspect 112(6):703-709.

Guo-Ross SX, Chambers JE, Meek EC, Carr RL. 2007. Altered muscarinic acetylcholine receptor subtype binding in neonatal rat brain following exposure to chlorpyrifos or methyl parathion. Toxicol Sci 100(1):118-127.

Haviland JA, Butz DE, Porter WP. 2010. Long-term sex selective hormonal and behavior alterations in mice exposed to low doses of chlorpyrifos in utero. Reprod Toxicol 29(1):74-79.

Howard AS, Bucelli R, Jett DA, Bruun D, Yang D, Lein PJ. 2005 Sep 1. Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures. Toxicol Appl Pharmacol 207(2):112-124.

Icenogle LM, Christopher NC, Blackwelder WP, Caldwell DP, Qiao D, Seidler FJ, Slotkin TA, Levin ED. 2004. Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. Neurotoxicology & Teratology 26(1):95-101.

Johnson DE, Seidler FJ, Slotkin TA. 1998. Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chlorpyrifos. Brain Res Bull 45(2):143-147.

Johnson FO, Chambers JE, Nail CA, Givaruangsawat S, Carr RL. 2009. Developmental Chlorpyrifos and Methyl Parathion Exposure Alters Radial-Arm Maze Performance in Juvenile and Adult Rats. Toxicol Sci 109(1):132-142.

Lassiter TL, Brimijoin S. 2008. Rats gain excess weight after developmental exposure to the organophosphorothionate pesticide, chlorpyrifos. Neurotoxicology & Teratology 30(2):125-130.

Levin ED, Addy N, Baruah A, Elias A, Christopher NC, Seidler FJ, Slotkin TA. 2002. Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicology & Teratology 24(6):733-741.

Levin ED, Addy N, Nakajima A, Christopher NC, Seidler FJ, Slotkin TA. 2001. Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Developmental Brain Research 130(1):83-89.

Mansour SA, Mossa AH. 2010. Adverse effects of lactational exposure to chlorpyrifos in suckling rats. Human & Experimental Toxicology 29(2):77-92.

Maurissen JPJ, Hoberman AM, Garman RH, Hanley TR. 2000. Lack of selective developmental neurotoxicity in rat pups from dams treated by gavage with chlorpyrifos. Toxicol Sci 57(2):250-263.

Meyer A, Seidler FJ, Aldridge JE, Slotkin TA. 2005. Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos. Toxicology & Applied Pharmacology 203(2):154-166.

Meyer A, Seidler FJ, Aldridge JE, Tate CA, Cousins MM, Slotkin TA. 2004. Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure. Environ Health Perspect 112(3):295-301.

Meyer A, Seidler FJ, Cousins MM, Slotkin TA. 2003. Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: When is adenylyl cyclase a target? Environ Health Perspect 111(16):1871-1876.

Meyer A, Seidler FJ, Slotkin TA. 2004. Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling. Environ Health Perspect 112(2):170-178.

Navarro HA, Basta PV, Seidler FJ, Slotkin TA. 2001. Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: a neural effect? Developmental Brain Research 130(2):249-252.

Qiao D, Seidler FJ, Abreu-Villaca Y, Tate CA, Cousins MM, Slotkin TA. 2004. Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. Developmental Brain Research 148(1):43-52.

Qiao D, Seidler FJ, Padilla S, Slotkin TA. 2002. Developmental neurotoxicity of chlorpyrifos: What is the vulnerable period? Environ Health Perspect 110(11):1097-1103.

Qiao D, Seidler FJ, Tate CA, Cousins MM, Slotkin TA. 2003. Fetal chlorpyrifos exposure: Adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. Environ Health Perspect 111(4):536-544.

Raines KW, Seidler FJ, Slotkin TA. 2001. Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos. Developmental Brain Research 130(1):65-72.

Rhodes MC, Seidler FJ, Qiao D, Tate CA, Cousins MM, Slotkin TA. 2004. Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats. Toxicology & Applied Pharmacology 195(2):203-217.

Ricceri L, Markina N, Valanzano A, Fortuna S, Cometa MF, Meneguz A, Calamandrei G. 2003. Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice. Toxicology & Applied Pharmacology 191(3):189-201.

Ricceri L, Venerosi A, Capone F, Cometa MF, Lorenzini P, Fortuna S, Calamandrei G. 2006. Developmental neurotoxicity of organophosphorous pesticides: fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice. Toxicol Sci 93(1):105-113.

Richardson JR, Chambers JE. 2004. Neurochemical effects of repeated gestational exposure to chlorpyrifos in developing rats. Toxicol Sci 77(1):83-90.

Richardson JR, Chambers JE. 2005. Effects of repeated oral postnatal exposure to chlorpyrifos on cholinergic neurochemistry in developing rats. Toxicol Sci 84(2):352-359.

Roy TS, Andrews JE, Seidler FJ, Slotkin TA. 1998. Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos. Teratology 58(2):62-68.

Roy TS, Seidler FJ, Slotkin TA. 2004. Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: regionally selective alterations in neurons and glia. Brain Res Dev Brain Res 148(2):197-206.

Roy TS, Sharma V, Seidler FJ, Slotkin TA. 2005. Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats. Developmental Brain Research 155(1):71-80.

Seidler FJ, Slotkin TA. 2011. Developmental neurotoxicity targeting hepatic and cardiac sympathetic innervation: effects of organophosphates are distinct from those of glucocorticoids. Brain Res Bull 85(3-4):225-230.

Slotkin TA, Brown KK, Seidler FJ. 2005. Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood. Environ Health Perspect 113(10):1291-1294.

Slotkin TA, Cousins MM, Tate CA, Seidler FJ. 2001. Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. Brain Res 902(2):229-243.

Slotkin TA, Levin ED, Seidler FJ. 2006. Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environ Health Perspect 114(5):746-751.

Slotkin TA, Oliver CA, Seidler FJ. 2005. Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination. Developmental Brain Research 157(2):172-180.

Slotkin TA, Seidler FJ, Fumagalli F. 2007. Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: Similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. Environ Health Perspect 115(6):909-916.

Slotkin TA, Seidler FJ, Fumagalli F. 2008. Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro. Brain Res Bull 76(4):424-38.

Slotkin TA, Seidler FJ. 2005. The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. Developmental Brain Research 158(1-2):115-119.

Slotkin TA, Seidler FJ. 2007. Comparative developmental neurotoxicity of organophosphates in vivo: Transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems. Brain Res Bull 72(4-6):232-274.

Slotkin TA, Seidler FJ. 2007. Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats. Brain Res Bull 73(4-6):301-309.

Slotkin TA, Seidler FJ. 2007. Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects. Reprod Toxicol 23(3):421-427.

Slotkin TA, Seidler FJ. 2012. Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro. Neurotoxicol Teratol 34(2):232-241.

Slotkin TA, Southard MC, Adam SJ, Cousins MM, Seidler FJ. 2004. 7 Nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: Nicotine and chlorpyrifos. Brain Res Bull 64(3):227-235.

Slotkin TA, Tate CA, Cousins MM, Seidler FJ. 2002. Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure. Developmental Brain Research 133(2):163-173.

Slotkin TA, Tate CA, Cousins MM, Seidler FJ. 2005. Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination. Developmental Brain Research 160(2):219-230.

Song X, Seidler FJ, Saleh JL, Zhang J, Padilla S, Slotkin TA. 1997. Cellular mechanisms for developmental toxicity of chlorpyrifos: Targeting the adenylyl cyclase signaling cascade. Toxicology & Applied Pharmacology 145(1):158-174.

Turgeman G, Pinkas A, Slotkin TA, Tfilin M, Langford R, Yanai J. 2011. Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by allographic transplantation of adult subventricular zone-derived neural stem cells. J Neurosci Res 89(8):1185-1193.

Venerosi A, Cutuli D, Colonnello V, Cardona D, Ricceri L, Calamandrei G. 2008. Neonatal exposure to chlorpyrifos affects maternal responses and maternal aggression of female mice in adulthood. Neurotoxicology & Teratology 30(6):468-474.

Whitney KD, Seidler FJ, Slotkin TA. 1995. Developmental neurotoxicity of chlorpyrifos: Cellular mechanisms. Toxicology & Applied Pharmacology 134(1):53-62.

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Perfluorinated Compounds (PFCs)

Abbott BD, Wolf CJ, Schmid JE, Das KP, Zehr RD, Helfant L, Nakayama S, Lindstrom AB, Strynar MJ, Lau C. 2007. Perfluorooctanoic acid induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha. Toxicol Sci 98(2):571-581.

Abbott BD, Wood CR, Watkins AM, Tatum-Gibbs K, Das KP, Lau C. 2012. Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues. Reprod Toxicol 33(4):491-505.

Bjork JA, Lau C, Chang SC, Butenhoff JL, Wallace KB. 2008. Perfluorooctane sulfonate-induced changes in fetal rat liver gene expression. Toxicology 251(1-3):8-20.

Butenhoff JL, Ehresman DJ, Chang SC, Parker GA, Stump DG. 2009. Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: developmental neurotoxicity. Reprod Toxicol 27(3-4):319-330.

Chang SC, Ehresman DJ, Bjork JA, Wallace KB, Parker GA, Stump DG, Butenhoff JL. 2009. Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: toxicokinetics, thyroid hormone status, and related gene expression. Reprod Toxicol 27(3-4):387-399.

Chen T, Zhang L, Yue JQ, Lv ZQ, Xia W, Wan YJ, Li YY, Xu SQ. 2012. Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring. Reprod Toxicol 33(4):538-545.

Dixon D, Reed CE, Moore AB, Gibbs-Flournoy EA, Hines EP, Wallace EA, Stanko JP, Lu Y, Jefferson WN, Newbold RR, Fenton SE. 2012. Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay. Reprod Toxicol 33(4):506-512.

Hines EP, White SS, Stanko JP, Gibbs-Flournoy EA, Lau C, Fenton SE. 2009. Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life. Mol Cell Endocrinol 304(1-2):97-105.

Johansson N, Fredriksson A, Eriksson P. 2008. Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice. Neurotoxicology 29(1):160-169.

Keil DE, Mehlmann T, Butterworth L, Peden-Adams MM. 2008. Gestational exposure to perfluorooctane sulfonate suppresses immune function in B6C3F1 mice. Toxicol Sci 103(1):77-85.

Lau C, Thibodeaux JR, Hanson RG, Narotsky MG, Rogers JM, Lindstrom AB, Strynar MJ. 2006. Effects of perfluorooctanoic acid exposure during pregnancy in the mouse. Toxicol Sci 90(2):510-518.

Lau C, Thibodeaux JR, Hanson RG, Rogers JM, Grey BE, Stanton ME, Butenhoff JL, Stevenson LA. 2003. Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation. Toxicol Sci 74(2):382-392.

Liu X, Liu W, Jin Y, Yu W, Wang F, Liu L. 2010. Effect of gestational and lactational exposure to perfluorooctanesulfonate on calcium-dependent signaling molecules gene expression in rats’ hippocampus. Arch Toxicol 84(1):71-79.

Luebker DJ, Case MT, York RG, Moore JA, Hansen KJ, Butenhoff JL. 2005. Two-generation reproduction and cross-foster studies of perfluorooctanesulfonate (PFOS) in rats. Toxicology 215(1-2):126-148.

Macon MB, Villanueva LR, Tatum-Gibbs K, Zehr RD, Strynar MJ, Stanko JP, White SS, Helfant L, Fenton SE. 2011. Prenatal perfluorooctanoic acid exposure in CD-1 mice: low-dose developmental effects and internal dosimetry. Toxicol Sci 122(1):134-145.

Onishchenko N, Fischer C, Wan Ibrahim WN, Negri S, Spulber S, Cottica D, Ceccatelli S. 2011. Prenatal exposure to PFOS or PFOA alters motor function in mice in a sex-related manner. Neurotox Res 19(3):452-461.

Rosen MB, Thibodeaux JR, Wood CR, Zehr RD, Schmid JE, Lau C. 2007. Gene expression profiling in the lung and liver of PFOA-exposed mouse fetuses. Toxicology 239(1-2):15-33.

Thibodeaux JR, Hanson RG, Rogers JM, Grey BE, Barbee BD, Richards JH, Butenhoff JL, Stevenson LA, Lau C. 2003. Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations. Toxicol Sci 74(2):369-381.

Wang F, Liu W, Jin Y, Dai J, Yu W, Liu X, Liu L. 2010. Transcriptional effects of prenatal and neonatal exposure to PFOS in developing rat brain. Environ Sci Technol 44(5):1847-1853.

Wang F, Liu W, Jin Y, Dai J, Zhao H, Xie Q, Liu X, Yu W, Ma J. 2011. Interaction of PFOS and BDE-47 co-exposure on thyroid hormone levels and TH-related gene and protein expression in developing rat brains. Toxicol Sci 121(2):279-291.

White SS, Calafat AM, Kuklenyik Z, Villanueva L, Zehr RD, Helfant L, Strynar MJ, Lindstrom AB, Thibodeaux JR, Wood C, Fenton SE. 2007. Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring. Toxicol Sci 96(1):133-144.

White SS, Kato K, Jia LT, Basden BJ, Calafat AM, Hines EP, Stanko JP, Wolf CJ, Abbott BD, Fenton SE. 2009. Effects of perfluorooctanoic acid on mouse mammary gland development and differentiation resulting from cross-foster and restricted gestational exposures. Reprod Toxicol 27(3-4):289-298.

White SS, Stanko JP, Kato K, Calafat AM, Hines EP, Fenton SE. 2011. Gestational and chronic low-dose PFOA exposures and mammary gland growth and differentiation in three generations of CD-1 mice. Environ Health Perspect 119(8):1070-1076.

Wolf CJ, Fenton SE, Schmid JE, Calafat AM, Kuklenyik Z, Bryant XA, Thibodeaux J, Das KP, White SS, Lau CS, Abbott BD. 2007. Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposures. Toxicol Sci 95(2):462-473.

Xia W, Wan Y, Li YY, Zeng H, Lv Z, Li G, Wei Z, Xu SQ. 2011. PFOS prenatal exposure induce mitochondrial injury and gene expression change in hearts of weaned SD rats. Toxicology 282(1-2):23-29.

Yahia D, El-Nasser MA, Abedel-Latif M, Tsukuba C, Yoshida M, Sato I, Tsuda S. 2010. Effects of perfluorooctanoic acid (PFOA) exposure to pregnant mice on reproduction. J Toxicol Sci 35(4):527-533.

Ye L, Zhao B, Yuan K, Chu Y, Li C, Zhao C, Lian QQ, Ge RS. 2012. Gene expression profiling in fetal rat lung during gestational perfluorooctane sulfonate exposure. Toxicol Lett 209(3):270-276.

Yu WG, Liu W, Jin YH, Liu XH, Wang FQ, Liu L, Nakayama SF. 2009. Prenatal and postnatal impact of perfluorooctane sulfonate (PFOS) on rat development: a cross-foster study on chemical burden and thyroid hormone system. Environ Sci Technol 43(21):8416-8422.

Zeng HC, Li YY, Zhang L, Wang YJ, Chen J, Xia W, Lin Y, Wei J, Lv ZQ, Li M, Xu SQ. 2011. Prenatal exposure to perfluorooctanesulfonate in rat resulted in long-lasting changes of expression of synapsins and synaptophysin. Synapse 65(3):225-233.

Zeng HC, Zhang L, Li YY, Wang YJ, Xia W, Lin Y, Wei J, Xu SQ. 2011. Inflammation-like glial response in rat brain induced by prenatal PFOS exposure. Neurotoxicology 32(1):130-139.

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